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Statin Use and Risk of Prostate Cancer: Results from a Population-based Epidemiologic Study.

Agalliu, Ilir and Salinas, Claudia A. and Hansten, Philip D. and Ostrander, Elaine A. and Stanford, Janet L. (2008) Statin Use and Risk of Prostate Cancer: Results from a Population-based Epidemiologic Study. American journal of epidemiology, 168 (3). pp. 250-260. ISSN 1476-6256

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Article URL: http://aje.oxfordjournals.org/cgi/content/abstract...

Abstract

Epidemiologic studies of statin use in relation to prostate cancer risk have been inconclusive. Recent evidence, however, suggests that longer-term use may reduce risk of more advanced disease. The authors conducted a population-based study of 1,001 incident prostate cancer cases diagnosed in 2002-2005 and 942 age-matched controls from King County, Washington, to evaluate risk associated with statin use. Logistic regression was used to generate odds ratios for ever use, current use, and duration of use. No overall association was found between statin use and prostate cancer risk (odds ratio (OR) = 1.0, 95% confidence interval (CI): 0.8, 1.2 for current use; OR = 1.1, 95% CI: 0.7, 1.8 for >10 years' use), even for cases with more advanced disease. Risk related to statin use, however, was modified by body mass index (interaction p = 0.04). Obese men (BMI >/=30 kg/m(2)) who used statins had an increased risk (OR = 1.5, 95% CI: 1.0, 2.2) relative to obese nonusers, with a stronger association for longer-term use (OR = 1.8, 95% CI: 1.1, 3.0 for >/=5 years' use). Although statin use was not associated with overall prostate cancer risk, the finding of an increased risk associated with statin use among obese men, particularly use for extended durations, warrants further investigation.

Item Type: Article
Additional Information: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version Am J Epidemiol. 2008 August 1; 168(3): 250–260 is available online at: http://aje.oxfordjournals.org/cgi/content/abstract/kwn141v1
DOI: 10.1093/aje/kwn141
PubMed ID: 18556686
NIHMSID: NIHMS51743
PMCID: PMC2585510
Grant Numbers: R01 CA092579-05, N01-CN-05230
Keywords or MeSH Headings: Adult, Aged, Biological Markers/blood, Body Mass Index, Case-Control Studies, Cytochrome P-450 CYP3A/genetics, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage, Incidence, Logistic Models, Male, Middle Aged, Obesity/complications/drug therapy, Odds Ratio, Prostatic Neoplasms/diagnosis/*epidemiology/genetics/*prevention & control, Questionnaires, Retrospective Studies, Risk Factors, Washington/epidemiology
Subjects: Research Methodologies > Epidemiology > Risk assessment
Diseases > Solid tumors > Prostate cancer
Depositing User: Library Staff
Date Deposited: 30 Jul 2008 17:56
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/10

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