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Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation.

Groudine, M and Eisenman, R and Weintraub, H (1981) Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation. Nature, 292 (5821). pp. 311-317. ISSN 0028-0836

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Article URL: http://www.nature.com/nature/journal/v292/n5821/ab...

Abstract

The transcriptionally active ev-3 and inactive ev-1 endogenous retrovirus loci in chick cells differ in that ev-3 is undermethylated, preferentially sensitive to DNase I digestion, and contains nuclease hypersensitive sites in each of its two long terminal repeats. Transient exposure of cells to 5-azacytidine, a cytosine analogue which cannot be methylated at the 5 position, results in the hypomethylation and transcriptional activation of ev-1, as well as the acquisition of at least one nuclease-hypersensitive site within the chromosomal domain of ev-1.

Item Type: Article
Additional Information: This article is available to Nature subscribers only at the link above.
DOI: 10.1038/292311a0
PubMed ID: 6166864
Keywords or MeSH Headings: Animals; Azacitidine/pharmacology; Cell Transformation, Viral; Chick Embryo; Chromatin/drug effects/ultrastructure; DNA/genetics; DNA Restriction Enzymes; Deoxyribonuclease I; Deoxyribonucleases; Endonucleases; Methylation; Retroviridae/genetics; Transcription, Genetic/drug effects;
Subjects: Organisms > Viruses > RNA viruses
Molecules > Chromosomes > Chromatin
Depositing User: Library Staff
Date Deposited: 05 Dec 2008 00:44
Last Modified: 07 May 2010 18:27
URI: http://authors.fhcrc.org/id/eprint/108

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