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Detection of a Myc-associated protein by chemical cross-linking.

Gillespie, D A and Eisenman, R N (1989) Detection of a Myc-associated protein by chemical cross-linking. Molecular and cellular biology, 9 (2). pp. 865-868. ISSN 0270-7306

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A single nuclear protein (Myc-associated protein) can be specifically cross-linked to avian Myc proteins by treatment of nuclei or cells with the reversible cross-linker dimethyl 3,3'-dithiobis-propionimidate. Myc-associated protein has a molecular weight of approximately 500,000, is not detectably phosphorylated and, in contrast to Myc, has a long apparent half-life of greater than 3 h.

Item Type: Article or Abstract
Additional Information: This article is freely available in PubMed Central and at the journal's website.
PubMed ID: 2651907
PMCID: PMC362670
Keywords or MeSH Headings: Animals; Cell Line, Transformed; Cross-Linking Reagents; Half-Life; Imidoesters; Molecular Weight; Proto-Oncogene Proteins/isolation & purification/metabolism; Proto-Oncogene Proteins c-myc;
Subjects: Molecules > Proteins
Molecules > Genes > Oncogenes
Depositing User: Library Staff
Date Deposited: 03 Dec 2008 23:14
Last Modified: 21 May 2010 22:40

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