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FH3, a v-myc avian retrovirus with limited transforming ability.

Chen, C and Biegalke, B J and Eisenman, R N and Linial, M L (1989) FH3, a v-myc avian retrovirus with limited transforming ability. Journal of virology, 63 (12). pp. 5092-100. ISSN 0022-538X

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Article URL: http://jvi.asm.org/cgi/reprint/63/12/5092

Abstract

We have isolated a new acute avian transforming virus which contains the oncogene myc. This virus, designated FH3, was isolated after injection of a 10-day-old chick embryo with avian leukosis virus. While FH3 shares many properties with other v-myc-containing avian retroviruses, it also has several unique properties. The primary target for transformation in vitro is chicken macrophages; infection of chicken fibroblasts does not lead to complete morphological transformation. FH3 also exhibits a limited host range, in that Japanese quail macrophages and fibroblasts are infected but are not completely transformed. FH3 induces in vivo a limited tumor type if injected into 10-day-old chick embryos; only a cranial myelocytoma, which does not appear to be metastatic, can be detected. The v-myc gene of FH3 is expressed predominantly as a P145 Gag-Myc protein which is encoded by a ca. 8-kilobase genomic RNA. This FH3-encoded polyprotein is localized in the nucleus of all infected cells, whether or not they are transformed.

Item Type: Article
Additional Information: This article is freely available in PubMed Central and at the journal's website.
PubMed ID: 2555545
PMCID: PMC251171
Grant Numbers: CA 28151, MV388
Keywords or MeSH Headings: Animals; Avian Leukosis/microbiology/pathology; Avian leukosis virus/genetics; Base Sequence; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chickens; Genes, Viral; Molecular Sequence Data; Oncogene Protein p55(v-myc); Oncogenes; Protein-Tyrosine Kinases/genetics; Restriction Mapping; Retroviridae Proteins, Oncogenic/genetics; Virion/genetics;
Subjects: Organisms > Viruses > RNA viruses
Molecules > Proteins
Molecules > Genes > Oncogenes
Depositing User: Library Staff
Date Deposited: 03 Dec 2008 22:33
Last Modified: 21 May 2010 22:43
URI: http://authors.fhcrc.org/id/eprint/128

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