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Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization.

Gilladoga, A D and Edelhoff, S and Blackwood, E M and Eisenman, R N and Disteche, C M (1992) Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization. Oncogene, 7 (6). pp. 1249-1251. ISSN 0950-9232


The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding activity. Here we report the mapping of the MAX gene to a single region on human chromosome 14 (bands q22-q24) and to mouse chromosome 12 (region D). Chromosome abnormalities linked to several neoplasms have been previously associated with this region on human chromosome 14. The mapping results also confirm a region of homology between human chromosome 14q22-24 and mouse chromosome 12 region D.

Item Type: Article or Abstract
Additional Information: This article does not have a URL available at the journal website.
PubMed ID: 1594250
Grant Numbers: T32CA09437, R01CA57138, 1-1019
Keywords or MeSH Headings: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; Chromosome Aberrations; Chromosome Banding; Chromosome Disorders; Chromosome Mapping; Chromosomes, Human, Pair 14; DNA-Binding Proteins/genetics; Humans; Mice; Neoplasms/genetics; Nucleic Acid Hybridization; Proto-Oncogene Proteins c-myc/genetics; Transcription Factors;
Subjects: Molecules > Proteins > Transcription factors
Cellular and Organismal Processes > Genetic processes > Mutation
Research Methodologies > Genomics > Gene mapping
Molecules > Genes > Oncogenes
Depositing User: Library Staff
Date Deposited: 03 Dec 2008 00:27
Last Modified: 21 May 2010 22:56

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