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Overexpressed max is not oncogenic and attenuates myc-induced lymphoproliferation and lymphomagenesis in transgenic mice.

Lindeman, G J and Harris, A W and Bath, M L and Eisenman, R N and Adams, J M (1995) Overexpressed max is not oncogenic and attenuates myc-induced lymphoproliferation and lymphomagenesis in transgenic mice. Oncogene, 10 (5). pp. 1013-7. ISSN 0950-9232

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Abstract

The cellular growth promoting function of the Myc oncoprotein requires its heterodimerization with the Max protein, but Max can also form complexes that inhibit Myc action. To determine whether max overexpression in vivo is oncogenic and whether it can modulate the action of Myc, we generated transgenic mice in which the max gene was directed to express in lymphoid cells by a linked immunoglobulin heavy chain enhancer (E mu). Expression of the transgene at substantially higher levels than the endogenous max gene did not perturb lymphoid homeostasis in adult animals nor predispose to lymphomagenesis. The numbers of B-lymphoid cells in very young animals were reduced. Moreover, analysis of bi-transgenic E mu-myc/E mu-max mice revealed that max overexpression attenuated the premalignant B-lymphoproliferative state induced by an E mu-myc transgene and reduced the rate of lymphoma onset. These results suggest that elevation of Max expression in vivo inhibits the function of Myc.

Item Type: Article
Additional Information: No URL available for this article at the journal's website.
PubMed ID: 7898919
Grant Numbers: CA20525/CA/, CA43540/CA/, CA57138/CA/
Keywords or MeSH Headings: Animals; B-Lymphocytes/physiology; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; Cell Division; DNA-Binding Proteins/genetics; Genes, myc; Hematopoiesis; Homeostasis; Lymphoma/etiology/prevention & control; Mice; Mice, Transgenic; Transcription Factors;
Subjects: Cell Types > Blood and Immune Cells > B-Lymphocytes
Molecules > Proteins > Transcription factors
Molecules > Genes > Oncogenes
Diseases > Hematologic and lymphatic diseases > Lymphoma
Depositing User: Library Staff
Date Deposited: 26 Nov 2008 22:25
Last Modified: 21 May 2010 23:12
URI: http://authors.fhcrc.org/id/eprint/152

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