Gallant, P and Shiio, Y and Cheng, P F and Parkhurst, S M and Eisenman, R N (1996) Myc and Max homologs in Drosophila. Science (New York, N.Y.), 274 (5292). pp. 1523-1527. ISSN 0036-8075
Abstract
The proteins encoded by the myc proto-oncogene family are involved in cell proliferation, apoptosis, differentiation, and neoplasia. Myc acts through dimerization with Max to bind DNA and activate transcription. Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products (dMyc and dMax) were shown to heterodimerize, recognize the same DNA sequence as their vertebrate homologs, and activate transcription. The dMyc protein is likely encoded by the Drosophila gene diminutive (dm), a mutation in which results in small body size and female sterility caused by degeneration of the ovaries. These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max.
| Item Type: | Article or Abstract |
|---|---|
| DOI: | 10.1126/science.274.5292.1523 |
| PubMed ID: | 8929412 |
| Grant Numbers: | R01CA57138, RO1GM47852 |
| Keywords or MeSH Headings: | Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; Cloning, Molecular; DNA Transposable Elements; DNA, Complementary; DNA-Binding Proteins/chemistry/genetics/metabolism; Dimerization; Drosophila Proteins; Drosophila melanogaster/chemistry/genetics/growth & development/metabolism; Female; Gene Expression Regulation, Developmental; Genes, Insect; Genes, myc; Helix-Loop-Helix Motifs; Humans; Molecular Sequence Data; Oligonucleotide Probes/metabolism; Ovary/metabolism; Proto-Oncogene Proteins c-myc/chemistry/genetics/metabolism; RNA, Messenger/genetics/metabolism; Transcription Factors/chemistry/genetics/metabolism; Transcription, Genetic; |
| Subjects: | Molecules > Proteins > Transcription factors Organisms > Model organisms Molecules > Genes > Oncogenes Cellular and Organismal Processes > Genetic processes > Transcription |
| Depositing User: | Library Staff |
| Date Deposited: | 26 Nov 2008 00:18 |
| Last Modified: | 07 May 2010 20:32 |
| URI: | http://authors.fhcrc.org/id/eprint/161 |
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