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Myc and Max homologs in Drosophila.

Gallant, P and Shiio, Y and Cheng, P F and Parkhurst, S M and Eisenman, R N (1996) Myc and Max homologs in Drosophila. Science (New York, N.Y.), 274 (5292). pp. 1523-1527. ISSN 0036-8075

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The proteins encoded by the myc proto-oncogene family are involved in cell proliferation, apoptosis, differentiation, and neoplasia. Myc acts through dimerization with Max to bind DNA and activate transcription. Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products (dMyc and dMax) were shown to heterodimerize, recognize the same DNA sequence as their vertebrate homologs, and activate transcription. The dMyc protein is likely encoded by the Drosophila gene diminutive (dm), a mutation in which results in small body size and female sterility caused by degeneration of the ovaries. These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max.

Item Type: Article
DOI: 10.1126/science.274.5292.1523
PubMed ID: 8929412
Grant Numbers: R01CA57138, RO1GM47852
Keywords or MeSH Headings: Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; Cloning, Molecular; DNA Transposable Elements; DNA, Complementary; DNA-Binding Proteins/chemistry/genetics/metabolism; Dimerization; Drosophila Proteins; Drosophila melanogaster/chemistry/genetics/growth & development/metabolism; Female; Gene Expression Regulation, Developmental; Genes, Insect; Genes, myc; Helix-Loop-Helix Motifs; Humans; Molecular Sequence Data; Oligonucleotide Probes/metabolism; Ovary/metabolism; Proto-Oncogene Proteins c-myc/chemistry/genetics/metabolism; RNA, Messenger/genetics/metabolism; Transcription Factors/chemistry/genetics/metabolism; Transcription, Genetic;
Subjects: Molecules > Proteins > Transcription factors
Organisms > Model organisms
Molecules > Genes > Oncogenes
Cellular and Organismal Processes > Genetic processes > Transcription
Depositing User: Library Staff
Date Deposited: 26 Nov 2008 00:18
Last Modified: 07 May 2010 20:32

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