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SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.

Laherty, C D and Billin, A N and Lavinsky, R M and Yochum, G S and Bush, A C and Sun, J M and Mullen, T M and Davie, J R and Rose, D W and Glass, C K and Rosenfeld, M G and Ayer, D E and Eisenman, R N (1998) SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Molecular cell, 2 (1). pp. 33-42. ISSN 1097-2765

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The transcriptional corepressor mSin3 is found in a large multiprotein complex containing the histone deacetylases HDAC1 and HDAC2, in addition to at least five tightly associated polypeptides. We have cloned and characterized a novel component of the mSin3 complex, SAP30, SAP30 binds to mSin3 and is capable of mediating transcriptional repression via histone deacetylases. SAP30 also binds the N-CoR corepressor and is required for N-CoR-mediated repression by antagonist-bound estrogen receptor and the homeodomain protein Rpx, as well as N-CoR suppression of transactivation by the POU domain protein Pit-1. However, SAP30 is not required for N-CoR-mediated repression by unliganded retinoic acid receptor or thyroid hormone receptor, suggesting that SAP30 is involved in the functional recruitment of the mSin3-histone deacetylase complex to a specific subset of N-CoR corepressor complexes.

Item Type: Article
Additional Information: This article is freely available from the journal website.
DOI: 10.1016/S1097-2765(00)80111-2
PubMed ID: 9702189
Keywords or MeSH Headings: Amino Acid Sequence; Animals; Cell Line, Transformed; DNA-Binding Proteins/physiology; Histone Deacetylases/genetics/physiology; Homeodomain Proteins/physiology; Humans; Kidney; Macromolecular Substances; Mice; Models, Genetic; Molecular Sequence Data; Multiprotein Complexes; Nuclear Proteins/physiology; Receptors, Estrogen/antagonists & inhibitors; Receptors, Retinoic Acid/physiology; Receptors, Thyroid Hormone/physiology; Repressor Proteins/physiology; Saccharomyces cerevisiae Proteins; Transcription Factor Pit-1; Transcription Factors/physiology; Transcription, Genetic; Transfection;
Subjects: Molecules > Proteins > Transcription factors
Cellular and Organismal Processes > Genetic processes > Transcription
Depositing User: Library Staff
Date Deposited: 25 Nov 2008 21:15
Last Modified: 07 May 2010 20:45

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