Johnston, L A and Prober, D A and Edgar, B A and Eisenman, R N and Gallant, P (1999) Drosophila myc regulates cellular growth during development. Cell, 98 (6). pp. 779-790. ISSN 0092-8674
Abstract
Transcription factors of the Myc proto-oncogene family promote cell division, but how they do this is poorly understood. Here we address the functions of Drosophila Myc (dMyc) during development. Using mosaic analysis in the fly wing, we show that loss of dMyc retards cellular growth (accumulation of cell mass) and reduces cell size, whereas dMyc overproduction increases growth rates and cell size. dMyc-induced growth promotes G1/S progression but fails to accelerate cell division because G2/M progression is independently controlled by Cdc25/String. We also show that the secreted signal Wingless patterns growth in the wing primordium by modulating dMyc expression. Our results indicate that dMyc links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism.
| Item Type: | Article or Abstract |
|---|---|
| Additional Information: | This article is freely available at the journal's website. |
| DOI: | 10.1016/S0092-8674(00)81512-3 |
| PubMed ID: | 10499795 |
| Keywords or MeSH Headings: | Alleles; Animals; Body Constitution/genetics; Body Patterning/genetics; Cell Cycle/genetics; Cell Size/genetics; DNA-Binding Proteins; Drosophila/genetics/growth & development; Drosophila Proteins; Female; Fetal Viability/genetics; Infertility; Mosaicism; Mutation; Proto-Oncogene Proteins c-myc/genetics; Transcription Factors/genetics; Wing/growth & development; |
| Subjects: | Molecules > Proteins > Transcription factors Cellular and Organismal Processes > Development Molecules > Genes > Oncogenes Cellular and Organismal Processes > Cell Physiology > Cell cycle |
| Depositing User: | Library Staff |
| Date Deposited: | 25 Nov 2008 19:52 |
| Last Modified: | 07 May 2010 20:48 |
| URI: | http://authors.fhcrc.org/id/eprint/170 |
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