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c-Myc enhances protein synthesis and cell size during B lymphocyte development.

Iritani, B M and Eisenman, R N (1999) c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America, 96 (23). pp. 13180-13185. ISSN 0027-8424

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Members of the myc family of nuclear protooncogenes play roles in cell proliferation, differentiation, and apoptosis. Moreover, inappropriate expression of c-myc genes contributes to the development of many types of cancers, including B cell lymphomas in humans. Although Myc proteins have been shown to function as transcription factors, their immediate effects on the cell have not been well defined. Here we have utilized a murine model of lymphomagenesis (Emu-myc mice) to show that constitutive expression of a c-myc transgene under control of the Ig heavy-chain enhancer (Emu) results in an increase in cell size of normal pretransformed B lymphocytes at all stages of B cell development. Furthermore, we show that c-Myc-induced growth occurs independently of cell cycle phase and correlates with an increase in protein synthesis. These results suggest that Myc may normally function by coordinating expression of growth-related genes in response to mitogenic signals. Deregulated c-myc expression may predispose to cancer by enhancing cell growth to levels required for unrestrained cell division.

Item Type: Article or Abstract
Additional Information: This article is freely available in PubMed Central and at the journal's website.
DOI: 10.1073/pnas.96.23.13180
PubMed ID: 10557294
Grant Numbers: 1 K08 AJ01445-01, RO1CA20525, HL54881
Keywords or MeSH Headings: Animals; B-Lymphocytes/cytology; Cell Cycle; Cell Size/physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proto-Oncogene Proteins c-myc/biosynthesis/physiology; Transgenes;
Subjects: Cell Types > Blood and Immune Cells > B-Lymphocytes
Molecules > Genes > Oncogenes
Cellular and Organismal Processes > Cell Physiology > Cell cycle
Depositing User: Library Staff
Date Deposited: 25 Nov 2008 19:43
Last Modified: 04 Oct 2011 22:44

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