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Myc: a weapon of mass destruction.

Secombe, Julie and Pierce, Sarah B and Eisenman, Robert N (2004) Myc: a weapon of mass destruction. Cell, 117 (2). pp. 153-156. ISSN 0092-8674

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Growth and proliferation potentiated by deregulated myc oncogene expression is balanced by myc-induced apoptosis. Abrogation of this apoptotic pathway in Myc overexpressing cells leads to cancer progression. Recent work has shown that cell clones in the Drosophila wing disc with higher dMyc expression levels act as supercompetitors to potentiate the programmed death of surrounding normal cells. Yet another paper identifies dE2F1 as a critical component of pathways that normally restrict the ability of growth perturbing genes like dMyc to cause organ overgrowth.

Item Type: Article or Abstract
Additional Information: This article is freely available at the Article URL above.
DOI: 10.1016/S0092-8674(04)00336-8
PubMed ID: 15084254
Keywords or MeSH Headings: Animals; Apoptosis/genetics; Cell Cycle Proteins; Cell Division/genetics; Cell Transformation, Neoplastic/genetics/metabolism; DNA-Binding Proteins/genetics; Drosophila Proteins/genetics; E2F Transcription Factors; Genes, myc/genetics; Humans; Proto-Oncogene Proteins c-myc/genetics; Signal Transduction/genetics; Transcription Factors/genetics;
Subjects: Cellular and Organismal Processes > Cell Physiology > Cell death
Cellular and Organismal Processes > Cell Physiology > Cell proliferation
Molecules > Genes > Oncogenes
Depositing User: Library Staff
Date Deposited: 16 Dec 2008 00:21
Last Modified: 13 May 2010 20:57

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