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Tumor suppression and normal aging in mice with constitutively high p53 activity.

Mendrysa, Susan M and O'Leary, Kathleen A and McElwee, Matthew K and Michalowski, Jennifer and Eisenman, Robert N and Powell, Douglas A and Perry, Mary Ellen (2006) Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes & development, 20 (1). pp. 16-21. ISSN 0890-9369

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The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compare the effects of decreased levels of Mdm2 and hence increased p53 activity on tumorigenesis and life span in mice. Here we report that mice with decreased levels of Mdm2 are resistant to tumor formation yet do not age prematurely, supporting the notion that Mdm2 is a promising target for cancer therapeutics.

Item Type: Article or Abstract
Additional Information: This article is freely available in PubMed Central and at the journal's website via the Article URL above.
DOI: 10.1101/gad.1378506
PubMed ID: 16391230
PMCID: PMC1356096
Keywords or MeSH Headings: Aging/metabolism; Animals; Bone and Bones/metabolism/pathology; Intestinal Neoplasms/metabolism/pathology; Leukocyte Count; Mice; Mice, Mutant Strains; Proto-Oncogene Proteins c-mdm2/genetics/metabolism; Skin/metabolism/pathology; Survival Rate; Tumor Suppressor Protein p53/genetics/metabolism;
Subjects: Cellular and Organismal Processes > Aging
Molecules > Genes > Oncogenes
Depositing User: Library Staff
Date Deposited: 17 Dec 2008 20:39
Last Modified: 10 May 2010 22:13

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