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Comprehensive Analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 Loci and Squamous Cell Cervical Cancer Risk

Madeleine, Margaret M. and Johnson, Lisa G. and Smith, Anajane G. and Hansen, John A. and Nisperos, Brenda B. and Li, Sue and Zhao, Lue-Ping and Daling, Janet R. and Schwartz, Stephen M. and Galloway, Denise A. (2008) Comprehensive Analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 Loci and Squamous Cell Cervical Cancer Risk. Cancer Research, 68 (9). pp. 3532-3539. ISSN 1538-7445

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Article URL: http://cancerres.aacrjournals.org/cgi/content/full...

Abstract

Variation in human major histocompatibility genes may influence the risk of squamous cell cervical cancer (SCC) by altering the efficiency of the T-cell–mediated immune response to human papillomavirus (HPV) antigens. We used high-resolution methods to genotype human leukocyte antigen (HLA) class I (A, B, and Cw) and class II (DRB1 and DQB1) loci in 544 women with SCC and 542 controls. Recognizing that HLA molecules are codominantly expressed, we focused on co-occurring alleles. Among 137 allele combinations present at >5% in the case or control groups, 36 were significantly associated with SCC risk. All but one of the 30 combinations that increased risk included DQB1*0301, and 23 included subsets of A*0201-B*4402-Cw*0501-DRB1*0401-DQB1*0301. Another combination, B*4402-DRB1*1101-DQB1*0301, conferred a strong risk of SCC (odds ratio, 10.0; 95% confidence interval, 3.0–33.3). Among the six combinations that conferred a decreased risk of SCC, four included Cw*0701 or DQB1*02. Most multilocus results were similar for SCC that contained HPV16; a notable exception was A*0101-B*0801-Cw*0701-DRB1*0301-DQB1*0201 and its subsets, which were associated with HPV16-positive SCC (odds ratio, 0.5; 95% confidence interval, 0.3–0.9). The main multilocus associations were replicated in studies of cervical adenocarcinoma and vulvar cancer. These data confirm that T helper and cytotoxic T-cell responses are both important cofactors with HPV in cervical cancer etiology and indicate that co-occurring HLA alleles across loci seem to be more important than individual alleles. Thus, certain co-occurring alleles may be markers of disease risk that have clinical value as biomarkers for targeted screening or development of new therapies.

Item Type: Article
Additional Information: This article is available to subscribers only via the URL above for the first 12 months post-publication.
DOI: 10.1158/0008-5472.CAN-07-6471
PubMed ID: 18451182
NIHMSID: NIHMSID85424
PMCID: PMC2662593
Grant Numbers: R01 CA112512-03, P01 CA042792-19A1, P30 ES007033-13
Keywords or MeSH Headings: Adolescent; Adult; Age Distribution; Aged; Carcinoma, Squamous Cell/epidemiology/*genetics; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-A Antigens/analysis/*genetics; HLA-B Antigens/analysis/*genetics; HLA-C Antigens/analysis/*genetics; HLA-DQ Antigens/analysis/*genetics; HLA-DR Antigens/analysis/*genetics; Humans; Membrane Glycoproteins/analysis/*genetics; Middle Aged; Prevalence; Risk Factors; Sexual Partners; Smoking/epidemiology; Uterine Cervical Neoplasms/epidemiology/*genetics
Subjects: Diseases > Solid tumors > Cervical cancer
Cellular and Organismal Processes > Immune Response
Molecules > Antigens > HLA antigens
Depositing User: Library Staff
Date Deposited: 02 Apr 2009 18:34
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/215

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