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Effects of personal characteristics on serum CA125, mesothelin, and HE4 levels in healthy postmenopausal women at high-risk for ovarian cancer.

Lowe, Kimberly A and Shah, Chirag and Wallace, Erin and Anderson, Garnet and Paley, Pamela and McIntosh, Martin and Andersen, M Robyn and Scholler, Nathalie and Bergan, Lindsay and Thorpe, Jason and Urban, Nicole and Drescher, Charles W (2008) Effects of personal characteristics on serum CA125, mesothelin, and HE4 levels in healthy postmenopausal women at high-risk for ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (9). pp. 2480-2487. ISSN 1055-9965

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OBJECTIVE: To evaluate if serum levels of candidate ovarian cancer biomarkers vary with individual characteristics of healthy women who are likely candidates for an ovarian cancer screening program. METHODS: We analyzed serum CA125, mesothelin, and HE4 levels in a sample of 155 healthy postmenopausal women at increased risk for developing ovarian cancer based on personal and family cancer history. Information on reproductive, family and medical histories, lifestyle factors, and anthropometry was collected by self-report. Twenty-two factors were examined using univariate and multiple linear regression models for the three biomarker levels. RESULTS: In the multivariate models, CA125 levels were significantly higher in women who had used talcum powder (P = 0.02) and were lower in women who were parous (P = 0.05). Mesothelin levels were significantly higher in older women (P = 0.01) and lower in heavier women (P = 0.03). HE4 levels were higher in older women (P = 0.001) and in women who began menstruating at an older age (P = 0.03). CONCLUSIONS: CA125, mesothelin, and HE4 levels in healthy, postmenopausal women at increased risk for ovarian cancer are significantly associated with a few ovarian cancer risk factors. Since the effects of these personal characteristics on these serum markers are not large, their incorporation in screening algorithms may be unnecessary. This is true especially if a longitudinal algorithm is used because the marker level at the previous screen reflects personal characteristics such as age, body mass index, and age of menarche. Understanding the influence of personal factors on levels of novel early detection markers in healthy, unaffected women may have clinical utility in interpreting biomarker levels.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only at the URL above until September 1, 2009.
DOI: 10.1158/1055-9965.EPI-08-0150
PubMed ID: 18768519
PMCID: PMC2632599
Grant Numbers: P50 CA083636-10
Keywords or MeSH Headings: Anthropometry; CA-125 Antigen/blood; Epididymal Secretory Proteins/metabolism; Female; Humans; Life Style; Linear Models; Membrane Glycoproteins/blood; Ovarian Neoplasms/blood/pathology; Postmenopause; Risk; Tumor Markers, Biological/blood;
Subjects: Diseases > Solid tumors > Ovarian cancer
Research Methodologies > Genomics > Molecular Markers
Research Methodologies > Epidemiology > Risk assessment
Depositing User: Library Staff
Date Deposited: 09 Jan 2009 21:17
Last Modified: 14 Feb 2012 14:42

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