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Vitamin D Pathway Gene Variants and Prostate Cancer Risk

Holt, S.K. and Kwon, E.M. and Peters, U. and Ostrander, E.A. and Stanford, J.L. (2009) Vitamin D Pathway Gene Variants and Prostate Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 18 (6). pp. 1929-1933. ISSN 1055-9965

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Vitamin D has antiproliferative, antiangiogenic, and apoptotic properties. There is some evidence supporting an association between vitamin D-related gene variants and prostate cancer risk. We report results from this population-based case-control study of genes encoding for the vitamin D receptor (VDR), the vitamin D activating enzyme 1-alpha-hydroxylase (CYP27B1), and deactivating enzyme 24-hydroxylase (CYP24A1). Forty-eight tagging single nucleotide polymorphisms (tagSNP) were analyzed in 827 incident prostate cancer cases diagnosed from 2002 to 2005, and in 787 age-matched controls. Contrary to some earlier studies, we found no strong evidence of altered risk of developing prostate cancer overall or within clinical measures of tumor aggressiveness for any of the tagSNPs when they were assessed individually or in haplotypes.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above for the first 12 months following publication.
DOI: 10.1158/1055-9965.EPI-09-0113
PubMed ID: 19454612
PMCID: PMC2743676
Grant Numbers: R01 CA092579-05, P50 CA097186-07
Keywords or MeSH Headings: Adult; Aged; Case-Control Studies; Cytochrome P-450 CYP27A1/genetics*; Genetic Predisposition to Disease*; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prostatic Neoplasms/genetics*; Receptors, Calcitriol/genetics*; Risk Factors; Steroid Hydroxylases/genetics*; Vitamin D/genetics*; Vitamin D/metabolism
Subjects: Cellular and Organismal Processes > Genetic processes > Mutation
Research Methodologies > Epidemiology > Risk assessment
Diseases > Solid tumors > Prostate cancer
Depositing User: Library Staff
Date Deposited: 14 Jan 2010 19:25
Last Modified: 14 Feb 2012 14:42

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