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Analysis of recently identified prostate cancer susceptibility loci in a population-based study: Associations with family history and clinical features.

FitzGerald, Liesel M. and Kwon, Erika M. and Koopmeiners, Joseph S. and Salinas, Claudia A. and Stanford, Janet L. and Ostrander, Elaine A. (2009) Analysis of recently identified prostate cancer susceptibility loci in a population-based study: Associations with family history and clinical features. Clinical Cancer Research, 15 (9). pp. 3231-3237. ISSN 1557-3265

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Article URL: http://clincancerres.aacrjournals.org/cgi/reprint/...

Abstract

Purpose: Two recent genome-wide association studies have highlighted several SNPs purported to be associated with prostate cancer risk. We investigated the significance of these SNPs in a population-based study of Caucasian men, testing the effects of each SNP in relation to family history of prostate cancer and clinicopathological features of disease. Experimental Design: We genotyped 13 SNPs in 1,308 prostate cancer patients and 1,267 unaffected controls frequency matched to cases by five-year age groups. The association of each SNP with disease risk and stratified by family history of prostate cancer and clinicopathological features of disease was calculated using logistic and polytomous regression. Results: These results confirm the importance of multiple previously reported SNPs in relation to prostate cancer susceptibility; 11 of the 13 SNPs were significantly associated with risk of developing prostate cancer. However, none of the SNP associations were of comparable magnitude to that associated with having a first-degree family history of the disease. Risk estimates associated with SNPs rs4242382 and rs2735839 varied by family history, while risk estimates for rs10993994 and rs5945619 varied by Gleason score. Conclusions: Our results confirm that several recently identified SNPs are associated with prostate cancer risk; however the variant alleles only confer a low to moderate relative risk of disease and are generally not associated with more aggressive disease features.

Item Type: Article
Additional Information: This article is available to subscribers only via the URL above for the first 12 months post-publication.
DOI: 10.1158/1078-0432.CCR-08-2190
PubMed ID: 19366831
NIHMSID: NIHMS109078
PMCID: PMC2707085
Grant Numbers: R01 CA056678-05, R01 CA082664-03, R01 CA092579-05, P50 CA097186-07
Keywords or MeSH Headings: * Adult * Aged * Case-Control Studies * Genetic Predisposition to Disease* * Genome-Wide Association Study* * Genotype * Humans * Incidence * Male * Microsatellite Repeats * Middle Aged * Neoplasm Staging * Polymorphism, Single Nucleotide/genetics* * Prostatic Neoplasms/epidemiology * Prostatic Neoplasms/genetics* * Prostatic Neoplasms/pathology * Risk Factors * Survival Rate
Subjects: Cellular and Organismal Processes > Genetic processes > Mutation
Research Methodologies > Genomics > Gene mapping
Research Methodologies > Epidemiology
Diseases > Solid tumors > Prostate cancer
Depositing User: Library Staff
Date Deposited: 28 Apr 2009 18:47
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/225

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