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Reproductive outcomes in male childhood cancer survivors: a linked cancer-birth registry analysis

Chow, Eric J. and Kamineni, Aruna and Daling, Janet R. and Fraser, Alison and Wiggins, Charles L. and Mineau, Geraldine P. and Hamre, Merlin R. and Severson, Richard K. and Drews-Botsch, Carolyn and Mueller, Beth A. (2009) Reproductive outcomes in male childhood cancer survivors: a linked cancer-birth registry analysis. Archives of Pediatrics & Adolescent Medicine, 163 (10). pp. 887-894. ISSN 1072-4710

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OBJECTIVE: Compare the risk of reproductive and infant outcomes between male childhood cancer survivors and a population-based comparison group. DESIGN: Retrospective cohort study. SETTING: 4 U.S. regions. PARTICIPANTS: Cancer registries identified males <20 years old diagnosed with cancer 1973-2000. Linked birth certificates identified first subsequent live offspring (n=470). Comparison subjects were identified from remaining birth certificates, frequency-matched on year and age at fatherhood, and race/ethnicity (n=4150). MAIN EXPOSURE: Cancer diagnosis prior to age 20. OUTCOME MEASURES: Pregnancy and infant outcomes identified from birth certificates. RESULTS: Compared with infants born to unaffected males, offspring of cancer survivors had a borderline risk of birth weight <2500 g (RR 1.43, 95% CI 0.99-2.05), with risk associated most strongly with younger age of cancer diagnosis and exposure to any chemotherapy (RR 1.96, 95% CI 1.22-3.17) or radiotherapy (RR 1.95, 95% CI 1.14-3.35). However, they were not at risk of being born prematurely, small for gestational age, having malformations or an altered male:female sex ratio. Overall, female partners of male survivors were not more likely to have maternal complications recorded on birth records versus the comparison group. However, preeclampsia was associated with some cancers, especially central nervous system tumors (RR 3.36, 95% CI 1.63-6.90). CONCLUSIONS: Most pregnancies resulting in live births among partners of male childhood cancer survivors were not at significantly greater risk of complications versus comparison subjects. The possibility of a paternal component affected by prior cancer history influencing predisposition towards some adverse perinatal outcomes merits further investigation.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1001/archpediatrics.2009.111
PubMed ID: 19805706
PMCID: PMC2758644
Grant Numbers: N01 CN005230, N01 PC035141, N01-PC-05016-20, N01-CN-65064, N01-CN-67000, N01-PC-67006
Keywords or MeSH Headings: * Adolescent * Adult * Antineoplastic Agents/adverse effects* * Case-Control Studies * Child * Child, Preschool * Congenital Abnormalities/epidemiology * Female * Humans * Infant * Infant, Low Birth Weight * Infant, Newborn * Male * Neoplasms/drug therapy * Neoplasms/epidemiology* * Neoplasms/radiotherapy * Neoplasms/surgery * Paternal Exposure/adverse effects* * Pregnancy * Pregnancy Outcome* * Premature Birth/epidemiology * Radiotherapy/adverse effects* * Retrospective Studies * Survivors/statistics & numerical data* * United States/epidemiology
Subjects: Cellular and Organismal Processes > Reproduction
Research Methodologies > Epidemiology
Depositing User: Library Staff
Date Deposited: 29 Jan 2009 18:59
Last Modified: 14 Feb 2012 14:42

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