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Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women

Yong, Mellissa and Atkinson, Charlotte and Newton, Katherine M. and Aiello Bowles, Erin J. and Stanczyk, Frank Z. and Westerlind, Kim C. and Holt, Victoria L. and Schwartz, Stephen M. and Leisenring, Wendy M. and Lampe, Johanna W. (2009) Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women. Cancer Causes and Control, 20 (7). pp. 1039-1053. ISSN 0957-5243

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PURPOSE: Mammographic breast and bone mineral densities (BMD) have been associated with luteal phase hormone concentrations in premenopausal women. We assessed the associations of breast and bone densities with follicular phase hormones and sex hormone binding globulin (SHBG) in premenopausal women given that follicular phase hormones have been shown to be positively associated with premenopausal breast cancer risk. METHODS: One hundred and ninety two 40-45 year old women provided a spot urine and/or blood sample during the follicular phase. Hormone and SHBG concentrations and bone density were measured and routine mammograms were accessed and digitized to obtain breast density measures. Regression models were fit to assess the associations between hormones and SHBG and breast and bone densities. RESULTS: Positive associations were observed between percent breast density and SHBG (p trend = 0.02), as well as estradiol (p trend = 0.08), after controlling for body mass index (BMI), number of pregnancies, and breast feeding history. In addition, a statistically significant inverse association was observed between total testosterone and head BMD (p trend = 0.01), after controlling for BMI. CONCLUSIONS: Associations were observed between breast and bone densities and serum hormone concentrations during the follicular phase of the menstrual cycle.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1007/s10552-009-9321-3
PubMed ID: 19280356;
PMCID: PMC2817944
Grant Numbers: R01 CA097366-04
Keywords or MeSH Headings: * Adult * Bone Density* * Estrogens/metabolism * Female * Gonadal Steroid Hormones/metabolism* * Humans * Mammography* * Middle Aged * Premenopause/metabolism* * Sex Hormone-Binding Globulin/metabolism*
Subjects: Molecules > Hormones
Health Care > Womens Health
Depositing User: Library Staff
Date Deposited: 29 Jan 2009 18:40
Last Modified: 14 Feb 2012 14:43

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