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Formins in development: Orchestrating body plan origami.

Liu, Raymond and Linardopoulou, Elena V. and Osborn, Gregory E. and Parkhurst, Susan M. (2008) Formins in development: Orchestrating body plan origami. Biochimica et biophysica acta. ISSN 0006-3002 (In Press)

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Abstract

Formins, proteins defined by the presence of an FH2 domain and their ability to nucleate linear F-actin de novo, play a key role in the regulation of the cytoskeleton. Initially thought to primarily regulate actin, recent studies have highlighted a role for formins in the regulation of microtubule dynamics, and most recently have uncovered the ability of some formins to coordinate the organization of both the microtubule and actin cytoskeletons. While biochemical analyses of this family of proteins have yielded many insights into how formins regulate diverse cytoskeletal reorganizations, we are only beginning to appreciate how and when these functional properties are relevant to biological processes in a developmental or organismal context. Developmental genetic studies in fungi, Dictyostelium, vertebrates, plants and other model organisms have revealed conserved roles for formins in cell polarity, actin cable assembly and cytokinesis. However, roles have also been discovered for formins that are specific to particular organisms. Thus, formins perform both global and specific functions, with some of these roles concurring with previous biochemical data and others exposing new properties of formins. While not all family members have been examined across all organisms, the analyses to date highlight the significance of the flexibility within the formin family to regulate a broad spectrum of diverse cytoskeletal processes during development.

Item Type: Article
Additional Information: This article is available to subscribers only at the URL above.
DOI: 10.1016/j.bbamcr.2008.09.016
PubMed ID: 18996154
NIHMSID: NIHMS98776
PMCID: PMC2838992
Grant Numbers: R01 GM072581-03
Keywords or MeSH Headings: Animals Biological Evolution Body Patterning/physiology* Classification Cytoskeleton/metabolism Fetal Proteins/genetics Fetal Proteins/metabolism* Fungal Proteins/genetics Fungal Proteins/metabolism Humans Microfilament Proteins/genetics Microfilament Proteins/metabolism* Morphogenesis/physiology* Nuclear Proteins/genetics Nuclear Proteins/metabolism* Phylogeny Plant Proteins/genetics Plant Proteins/metabolism Protein Isoforms/classification Protein Isoforms/genetics Protein Isoforms/metabolism*
Subjects: Cellular and Organismal Processes > Development
Molecules > Proteins > Cytoskeletal proteins
Depositing User: Library Staff
Date Deposited: 03 Apr 2009 20:39
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/253

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