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Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk

Reding, Kerryn W. and Weiss, Noel S. and Chen, Chu and Li, Christopher I. and Carlson, Christopher S. and Wilkerson, Hui-Wen and Farin, Federico M. and Thummel, Kenneth E. and Daling, Janet R. and Malone, Kathleen E. (2009) Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk. Cancer Epidemiology Biomarkers and Prevention, 18 (5). pp. 1461-1467. ISSN 1538-7755

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Background: This study investigated whether single nucleotide polymorphisms (SNPs) in genes within the catechol estrogen metabolism pathway altered the risk of breast cancer alone or in combination, as well as whether menopausal hormone therapy (HT) modified the effect of these SNPs on breast cancer risk. Methods: In a population-based case-control study of breast cancer, 891 cases and 878 controls were genotyped for six functional SNPs in the COMT, CYP1B1, GSTM1, GSTP1, and GSTT1 genes. Results: Women homozygous with the T allele in CYP1B1*2 (Ser119; rs1056827) were at 1.69 (95% confidence interval [CI]: 1.17-2.46) times the risk of women homozygous with the G allele; women homozygous with the G allele in GSTP1 (Val105; rs1695) were at 0.73 (95% CI: 0.54-0.99) times the risk of breast cancer compared to women homozygous with the A allele. No other SNPs tested were associated with breast cancer to any appreciable degree. Potential gene-gene and gene-HT interactions were investigated. Conclusion: With the exception of GSTP1 and possibly CYP1B1*2, our findings do not provide support for the role of genetic variation in the catechol estrogen metabolism pathway and breast cancer risk in post-menopausal women.

Item Type: Article or Abstract
Additional Information: This article is available as an "Online First" article to subscribers only via the URL above.
DOI: 10.1158/1055-9965.EPI-08-0917
PubMed ID: 19383894
PMCID: PMC2764317
Grant Numbers: T32 CA009168-30, P30 ES007033-14, R01 CA072787-05
Keywords or MeSH Headings: * Aged * Alleles * Aryl Hydrocarbon Hydroxylases/genetics * Breast Neoplasms/epidemiology * Breast Neoplasms/genetics* * Case-Control Studies * Catechol O-Methyltransferase/genetics * Estrogens, Catechol/genetics* * Female * Genetic Predisposition to Disease * Glutathione S-Transferase pi/genetics * Glutathione Transferase/genetics * Haplotypes * Humans * Polymorphism, Single Nucleotide* * Postmenopause * Risk * SEER Program * Washington/epidemiology
Subjects: Diseases > Solid tumors > Breast cancer
Molecules > Hormones
Research Methodologies > Epidemiology > Risk assessment
Depositing User: Library Staff
Date Deposited: 28 Apr 2009 19:00
Last Modified: 14 Feb 2012 14:42

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