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Vegetable and fruit intakes and risk of Barrett's esophagus in men and women.

Thompson, Olivia M and Beresford, Shirley A A and Kirk, Elizabeth A and Vaughan, Thomas L (2009) Vegetable and fruit intakes and risk of Barrett's esophagus in men and women. The American journal of clinical nutrition, 89 (3). pp. 890-896. ISSN 0002-9165

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Article URL: http://www.ajcn.org/cgi/reprint/89/3/890

Abstract

BACKGROUND: Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma. Modifiable risk factors for BE are largely unknown. OBJECTIVE: The purpose of this study was to determine whether vegetable and fruit intakes are associated with BE risk. DESIGN: In a case-control study based in western Washington State, we compared the vegetable and fruit intakes of 170 patients with newly diagnosed BE with those of 182 controls from the general population. Relations between vegetable and fruit intakes and BE were examined by using unconditional logistic regression to compute odds ratios (ORs) and corresponding 95% CIs. RESULTS: Participants in the second (adjusted OR: 0.40; 95% CI: 0.23, 0.71) and third (adjusted OR: 0.33; 95% CI: 0.17, 0.63) tertiles of vegetable intake appeared to have a lower risk of BE (P for trend = 0.048) than did participants in the first tertile of vegetable intake. Similarly, participants in the second (adjusted OR: 0.49; 95% CI: 0.28, 0.86) and third (adjusted OR: 0.39; 95% CI: 0.21, 0.75) tertiles of combined vegetable and fruit intakes had a lower risk of BE (P for trend = 0.047) than did participants in the first tertile of vegetable and fruit intakes. Similar results were obtained in subanalyses limited to patients with visible and with long-segment BE. CONCLUSIONS: The results support previous findings that increased intakes of vegetables and of vegetables and fruit are associated with a lower risk of BE in men and women. Prospective data that examine relations between diet and BE are needed.

Item Type: Article
Additional Information: This article is freely available at the URL listed above.
DOI: 10.3945/ajcn.2008.26497
PubMed ID: 19144726
PMCID: PMC2667660
Grant Numbers: K05 CA124911-02, R01 CA072866-04, R25 CA092408-06
Keywords or MeSH Headings: Adult; Aged; Aged, 80 and over; Barrett Esophagus/epidemiology/prevention & control; Case-Control Studies; Eating; Female; Fruit; Humans; Logistic Models; Male; Middle Aged; Questionnaires; Vegetables; Young Adult;
Subjects: Diseases > Solid tumors > Digestive system cancer
Health Care > Risk and Preventive Health Services > Diet
Depositing User: Library Staff
Date Deposited: 03 Apr 2009 21:16
Last Modified: 07 Jul 2010 21:37
URI: http://authors.fhcrc.org/id/eprint/261

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