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Inverse association of NSAID use and ovarian cancer in relation to oral contraceptive use and parity.

Wernli, K J and Newcomb, P A and Hampton, J M and Trentham-Dietz, A and Egan, K M (2008) Inverse association of NSAID use and ovarian cancer in relation to oral contraceptive use and parity. British journal of cancer, 98 (11). pp. 1781-1783. ISSN 1532-1827

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We examined the association between non-steroidal anti-inflammatory drug (NSAID) use and ovarian cancer by potential effect modifiers, parity and oral contraceptive use, in a population-based case-control study conducted in Wisconsin and Massachusetts. Women reported prior use of NSAIDs and information on risk factors in a telephone interview. A total of 487 invasive ovarian cancer cases and 2653 control women aged 20-74 years were included in the analysis. After adjustment for age, state of residence and other covariates, ever use of NSAIDs was inversely associated with ovarian cancer in never users of oral contraceptives (odds ratio (OR)=0.58, 95% confidence interval (CI) 0.42-0.80) but not for ever users (OR=0.98, 95% CI 0.71-1.35) (P-interaction=0.03). A reduced risk with NSAID use was also noted in nulliparous women (OR=0.47, 95% CI 0.27-0.82) but not among parous women (OR=0.81, 95% CI 0.64-1.04) (P-interaction=0.05). These results suggest that use of NSAIDs were beneficial to women at greatest risk for ovarian cancer.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above for the first 12 months following publication. Twelve months after publication in British Journal of Cancer, the Contribution, as published on the BJC website, will be offered for reuse under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 licence, subject to the conditions listed at
DOI: 10.1038/sj.bjc.6604392
PubMed ID: 18506182
PMCID: PMC2410126
Grant Numbers: R01 CA047147-17, R01 CA047305-12
Keywords or MeSH Headings: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Case-Control Studies; Contraceptives, Oral/pharmacology; Female; Humans; Inflammation/complications; Middle Aged; Ovarian Neoplasms/etiology/prevention & control; Ovulation; Parity; Pregnancy;
Subjects: Diseases > Solid tumors > Ovarian cancer
Therapeutics > Drug Therapy
Depositing User: Library Staff
Date Deposited: 26 Mar 2009 16:54
Last Modified: 14 Feb 2012 14:42

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