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Hormone therapy in relation to survival from large bowel cancer.

Newcomb, Polly and Chia, Victoria M. and Hampton, John M. and Doria-Rose, V. Paul and Trentham Dietz, Amy (2009) Hormone therapy in relation to survival from large bowel cancer. Cancer causes & control : CCC, 20 (4). pp. 409-416. ISSN 1573-7225

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Epidemiologic studies of hormone therapy (HT) and colorectal cancer incidence consistently show an inverse association; however, few studies have considered prediagnostic use of HT on mortality among colorectal cancer patients. We evaluated the relationship of HT and survival among a population-based cohort of women with large bowel cancer. Cases (n = 1,297) were newly diagnosed with invasive cancer of the colon or rectum, aged 40-74 years at diagnosis, who were identified by Wisconsin's statewide registry (1988-1991; 1997-2001) for two case-control studies. Information on HT use and other colorectal cancer risk factors was collected by standardized interview. There were 507 deaths (274 of these attributable to colorectal cancer) over 8.4 years of follow-up through December 2005. Hormone use was not associated with colorectal cancer mortality (adjusted hazard rate ratio = 1.09, confidence interval = 0.81-1.47). Colorectal cancer specific mortality was not associated with HT when considered separately by preparation type. Stage did not modify this relationship. Long-term HT was weakly positively associated with increased mortality after diagnosis of proximal colon, but not distal colon cancer. Because we detected no differences in survival among users of HT compared to non-users, the results suggest that HT use may affect only the incidence of some colorectal tumors.

Item Type: Article or Abstract
Additional Information: The original publication is available at Full-text is available to subscribers only via the URL above.
DOI: 10.1007/s10552-008-9255-1
PubMed ID: 18998219
PMCID: PMC2728675
Grant Numbers: R01 CA047147-17
Keywords or MeSH Headings: * Adult * Aged * Case-Control Studies * Cohort Studies * Colorectal Neoplasms/diagnosis * Colorectal Neoplasms/epidemiology* * Colorectal Neoplasms/mortality* * Death Certificates * Estrogen Replacement Therapy/statistics & numerical data* * Female * Follow-Up Studies * Humans * Incidence * Interviews as Topic * Medical Record Linkage * Middle Aged * Population Surveillance * Proportional Hazards Models * Questionnaires * Registries * Retrospective Studies * Risk Factors * Survival Analysis * Time Factors * Wisconsin/epidemiology
Subjects: Diseases > Solid tumors > Digestive system cancer
Therapeutics > Drug Therapy
Depositing User: Library Staff
Date Deposited: 02 Apr 2009 23:02
Last Modified: 14 Feb 2012 14:42

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