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Serum retinol and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial.

Schenk, Jeannette M and Riboli, Elio and Chatterjee, Nilanjan and Leitzmann, Michael F and Ahn, Jiyoung and Albanes, Demetrius and Reding, Douglas J and Wang, Yinghui and Friesen, Marlin D and Hayes, Richard B and Peters, Ulrike (2009) Serum retinol and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 18 (4). pp. 1227-1231. ISSN 1055-9965

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Article URL: http://cebp.aacrjournals.org/cgi/reprint/18/4/1227

Abstract

Vitamin A (retinol) plays a key role in the regulation of cell growth and differentiation, and has been studied as a potential chemopreventive agent for prostate cancer. However, findings from epidemiologic studies on the association between circulating retinol concentrations and the risk of prostate cancer are inconsistent. We examined whether serum concentrations of retinol were associated with the risk of prostate cancer in a nested case-control study using 692 prostate cancer cases and 844 matched controls from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. We estimated the risk of prostate cancer using multivariate, conditional logistic regression to calculate odds ratios and 95% confidence intervals for overall prostate cancer and aggressive disease (stage III or IV or Gleason >7; n = 269). Serum retinol concentrations were not associated with overall prostate cancer risk; however, the highest versus lowest concentrations of serum retinol were associated with a 42% reduction in aggressive prostate cancer risk (P(trend) = 0.02), with the strongest inverse association for high-grade disease (Gleason sum >7; odds ratio, 0.52; 95% confidence interval, 0.32-0.84; P(trend) = 0.01). Our results suggest that higher circulating concentrations of retinol are associated with a decreased risk of aggressive prostate cancer. Further research is needed to better understand the significance of elevations in serum retinol concentrations and the possible biological mechanisms through which retinol affects prostate cancer. (Cancer Epidemiol Biomarkers Prev 2009;18(4):1227-31).

Item Type: Article
Additional Information: This article is available to subscribers only via the URL above for the first 12 months post-publication.
DOI: 10.1158/1055-9965.EPI-08-0984
PubMed ID: 19336558
NIHMSID: NIHMS109783
PMCID: PMC2717001
Grant Numbers: K22 CA118421-03, R25 CA094880-07
Keywords or MeSH Headings: * Aged * Case-Control Studies * Humans * Male * Mass Screening* * Middle Aged * Neoplasm Staging * Odds Ratio * Prostatic Neoplasms/blood* * Prostatic Neoplasms/epidemiology* * Questionnaires * Risk Factors * Tumor Markers, Biological/blood* * United States/epidemiology * Vitamin A/blood*
Depositing User: Library Staff
Date Deposited: 10 Apr 2009 22:52
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/274

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