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HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.

Sullivan, Ryan J and Pantanowitz, Liron and Casper, Corey and Stebbing, Justin and Dezube, Bruce J (2008) HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 47 (9). pp. 1209-1215. ISSN 1537-6591

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Article URL: http://www.journals.uchicago.edu/doi/pdf/10.1086/5...

Abstract

Kaposi sarcoma-associated herpesvirus infection is associated with the development of 3 proliferative diseases: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. These conditions are also intimately associated with human immunodeficiency virus infection, and important synergistic interactions between these 2 viruses have been described. Despite differences in viral gene expression patterns in each condition, Kaposi sarcoma-associated herpesvirus encodes similar oncogenic proteins that promote the activation of sequential and parallel signaling pathways. Therapeutic strategies have been implemented to target these unique signaling pathways, and this sort of molecular targeting is the focus of many current research efforts. The scope of this review is to present contemporary knowledge about the epidemiology, virology, and immunology of Kaposi sarcoma-associated herpesvirus and to highlight several key oncogene products that may be targets for chemotherapy.

Item Type: Article
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1086/592298
PubMed ID: 18808357
NIHMSID: NIHMS114928
PMCID: PMC2700291
Grant Numbers: U01 CA121947
Keywords or MeSH Headings: Giant Lymph Node Hyperplasia/epidemiology/physiopathology/therapy; Herpesviridae Infections/epidemiology/physiopathology/therapy; Herpesvirus 8, Human/pathogenicity; Humans; Immunocompromised Host; Lymphoma, Primary Effusion/epidemiology/physiopathology/therapy; Sarcoma, Kaposi/epidemiology/physiopathology/therapy;
Subjects: Diseases > Hematologic and lymphatic diseases
Diseases > Viral diseases
Organisms > Viruses > RNA viruses
Depositing User: Library Staff
Date Deposited: 04 May 2009 22:46
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/280

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