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New approaches to the treatment of human herpesvirus 8-associated disease.

Casper, Corey (2008) New approaches to the treatment of human herpesvirus 8-associated disease. Reviews in medical virology, 18 (5). pp. 321-329. ISSN 1052-9276

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Human herpesvirus 8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus or KSHV) is the etiologic agent of Kaposi sarcoma (KS) and primary effusion lymphoma (PEL), as well as many cases of Castleman disease. Despite significant advances in understanding the biology and natural history of these diseases, current treatment options have important limitations, and strategies to prevent their development in high-risk individuals are lacking. This article reviews the scope of HHV-8-associated disease, as well as the efficacy of current treatment options. Finally, novel approaches to treatment and prevention are described, including antiviral agents, targeted molecular therapy and a combination of these modalities.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1002/rmv.583
PubMed ID: 18615774
PMCID: PMC2711900
Grant Numbers: K23 AI054162-05
Keywords or MeSH Headings: Antiviral Agents/therapeutic use; Clinical Trials as Topic; Ganciclovir/analogs & derivatives/therapeutic use; Giant Lymph Node Hyperplasia/drug therapy/immunology/pathology/virology; Herpesviridae Infections/classification/drug therapy/epidemiology/therapy/virology; Herpesvirus 8, Human/drug effects; Humans; Lymphoma, Primary Effusion/drug therapy/epidemiology/pathology; Sarcoma, Kaposi/drug therapy/epidemiology/pathology;
Subjects: Diseases > Viral diseases
Depositing User: Library Staff
Date Deposited: 11 May 2009 23:18
Last Modified: 14 Feb 2012 14:42

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