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Biomarker-calibrated energy and protein consumption and increased cancer risk among postmenopausal women.

Prentice, Ross L and Shaw, Pamela A and Bingham, Sheila A and Beresford, Shirley A A and Caan, Bette and Neuhouser, Marian L and Patterson, Ruth E and Stefanick, Marcia L and Satterfield, Suzanne and Thomson, Cynthia A and Snetselaar, Linda and Thomas, Asha and Tinker, Lesley F (2009) Biomarker-calibrated energy and protein consumption and increased cancer risk among postmenopausal women. American journal of epidemiology, 169 (8). pp. 977-989. ISSN 1476-6256

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The authors previously reported equations, derived from the Nutrient Biomarker Study within the Women's Health Initiative, that produce calibrated estimates of energy, protein, and percentage of energy from protein consumption from corresponding food frequency questionnaire estimates and data on other factors, such as body mass index, age, and ethnicity. Here, these equations were applied to yield calibrated consumption estimates for 21,711 women enrolled in the Women's Health Initiative dietary modification trial comparison group and 59,105 women enrolled in the observational study. These estimates were related prospectively to total and site-specific invasive cancer incidence (1993-2005). In combined cohort analyses that do not control for body mass, uncalibrated energy was not associated with total cancer incidence or site-specific cancer incidence for most sites, whereas biomarker-calibrated energy was positively associated with total cancer (hazard ratio = 1.18, 95% confidence interval: 1.10, 1.27, for 20% consumption increase), as well as with breast, colon, endometrial, and kidney cancer (respective hazard ratios of 1.24, 1.35, 1.83, and 1.47). Calibrated protein was weakly associated, and calibrated percentage of energy from protein was inversely associated, with total cancer. Calibrated energy and body mass index associations were highly interdependent. Implications for the interpretation of nutritional epidemiology studies are described.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1093/aje/kwp008
PubMed ID: 19258487
PMCID: PMC2732977
Grant Numbers: N01WH22110, N01WH24152, N01WH32100-2,, N01WH32105-6, N01WH32108-9, N01WH32111-13, N01WH32115, N01WH32118-19, N01WH32122, N01WH42107-26, N01WH42129-32, N01WH44221, CA53996
Keywords or MeSH Headings: Aged; Dietary Proteins/administration & dosage; Energy Intake; Female; Food Habits; Humans; Incidence; Life Style; Middle Aged; Neoplasms/classification/epidemiology/metabolism; Nutrition Assessment; Postmenopause/metabolism; Proportional Hazards Models; Risk Assessment; Tumor Markers, Biological/metabolism;
Depositing User: Library Staff
Date Deposited: 19 May 2009 23:00
Last Modified: 14 Feb 2012 14:42

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