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A mother's sacrifice: what is she keeping for herself?

Henderson, Kiersten A and Gottschling, Daniel E (2008) A mother's sacrifice: what is she keeping for herself? Current opinion in cell biology, 20 (6). pp. 723-728. ISSN 1879-0410

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Individual cells of the budding yeast, Saccharomyces cerevisiae, have a limited life span and undergo a form of senescence termed replicative aging. Replicative life span is defined as the number of daughter cells produced by a yeast mother cell before she ceases dividing. Replicative aging is asymmetric: a mother cell ages but the age of her daughter cells is 'reset' to zero. Thus, one or more senescence factors have been proposed to accumulate asymmetrically between mother and daughter yeast cells and lead to mother-specific replicative senescence once a crucial threshold has been reached. Here we evaluate potential candidates for senescence factors and age-associated phenotypes and discuss potential mechanisms underlying the asymmetry of replicative aging in budding yeast.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1016/
PubMed ID: 18848886
PMCID: PMC2612538
Grant Numbers: R01 AG023779, R01 GM043893
Keywords or MeSH Headings: Cell Division; DNA Replication; DNA, Fungal/genetics/metabolism; DNA, Ribosomal/genetics/metabolism; Gene Expression Regulation, Fungal; Genes, Fungal; Models, Biological; Oxygen/metabolism; Phenotype; Saccharomyces cerevisiae/cytology/metabolism; Saccharomyces cerevisiae Proteins/genetics/metabolism;
Subjects: Cellular and Organismal Processes > Aging
Organisms > Model organisms
Cellular and Organismal Processes > Cell Physiology > Cell cycle
Depositing User: Library Staff
Date Deposited: 29 Jun 2009 18:40
Last Modified: 14 Feb 2012 14:42

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