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Aging and genetic instability in yeast.

McMurray, Michael A and Gottschling, Daniel E (2004) Aging and genetic instability in yeast. Current opinion in microbiology, 7 (6). pp. 673-679. ISSN 1369-5274

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Article URL: http://dx.doi.org/10.1016/j.mib.2004.10.008

Abstract

There is a striking link between increasing age and the incidence of cancer in humans. One of the hallmarks of cancer, genomic instability, has been observed in all types of organisms. In the yeast Saccharomyces cerevisiae, it was recently discovered that during the replicative lifespan, aging cells switch to a state of high genomic instability that persists until they die. In considering these and other recent results, we suggest that accumulation of oxidatively damaged protein in aging cells results in the loss of function of gene products critical for maintaining genome integrity. Determining the identity of these proteins and how they become damaged represents a new challenge for understanding the relationship between age and genetic instability.

Item Type: Article
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1016/j.mib.2004.10.008
PubMed ID: 15556042
Keywords or MeSH Headings: Gene Expression Regulation, Fungal; Genome, Fungal; Genomic Instability; Humans; Loss of Heterozygosity; Saccharomyces cerevisiae/genetics/physiology; Time Factors;
Subjects: Cellular and Organismal Processes > Aging
Cellular and Organismal Processes > Genetic processes > Genomic instability
Depositing User: Library Staff
Date Deposited: 29 Jun 2009 22:13
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/305

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