Arnold Library

Relationship between migraine history and breast cancer risk among premenopausal and postmenopausal women.

Li, Christopher I and Mathes, Robert W and Malone, Kathleen E and Daling, Janet R and Bernstein, Leslie and Marchbanks, Polly A and Strom, Brian L and Simon, Michael S and Press, Michael F and Deapen, Dennis and Burkman, Ronald T and Folger, Suzanne G and McDonald, Jill A and Spirtas, Robert (2009) Relationship between migraine history and breast cancer risk among premenopausal and postmenopausal women. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 18 (7). pp. 2030-2034. ISSN 1538-7755

[thumbnail of Complete manuscript]
Text (Complete manuscript)
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (87kB) | Preview
Article URL:


Both migraine and breast cancer are hormonally mediated diseases, and it is biologically plausible that women with a history of migraine may have a reduced breast cancer risk. However, this relationship has only been assessed in a single relatively small study that was unable to assess the effect of migraine triggers, which are also well-established breast cancer risk factors (e.g., use of alcohol and exogenous hormones), on the inverse association observed. Utilizing data on 4,568 breast cancer cases and 4,678 controls who participated in a multicenter population-based case-control study in the United States, we evaluated the association between migraine history and breast cancer risk using unconditional logistic regression. Migraine history data were obtained from structured in-person interviews. Women with a history of migraine had a reduced risk of breast cancer [odds ratio, 0.74; 95% confidence interval (CI), 0.66-0.82]. This risk did not differ by menopausal status, age at migraine diagnosis, use of prescription migraine medications, or when analyses were restricted to women who avoided various migraine triggers (including alcohol, exogenous hormones, and smoking). These data support a previous finding that a history of migraine may be associated with a reduced risk of breast cancer. It extends the prior report in observing that this relationship holds for both premenopausal and postmenopausal women and is independent of exposure to common migraine triggers.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above for the first 12 months following publication.
DOI: 10.1158/1055-9965.EPI-09-0291
PubMed ID: 19589913
PMCID: PMC2756173
Grant Numbers: N01-HD-2-3168, N01-HD-2-3166, N01-HD-3-3174, N01-HD-3-3176, N01-HD-3-3175, Y01-HD-7022
Keywords or MeSH Headings: * Adult * Breast Neoplasms/epidemiology* * Carcinoma, Ductal, Breast/epidemiology* * Carcinoma, Lobular/epidemiology* * Case-Control Studies * Confidence Intervals * Female * Humans * Logistic Models * Middle Aged * Migraine Disorders/epidemiology* * Odds Ratio * Postmenopause* * Premenopause* * Questionnaires * Registries * Risk Assessment * United States/epidemiology
Subjects: Diseases > Solid tumors > Breast cancer
Molecules > Hormones
Research Methodologies > Epidemiology > Risk assessment
Depositing User: Library Staff
Date Deposited: 24 Jul 2009 17:26
Last Modified: 14 Feb 2012 14:42

Repository Administrators Only

View Item View Item