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Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortium.

Johnatty, Sharon E and Beesley, Jonathan and Chen, Xiaoqing and Spurdle, Amanda B and Defazio, Anna and Webb, Penelope M and Goode, Ellen L and Rider, David N and Vierkant, Robert A and Anderson, Stephanie and Wu, Anna H and Pike, Malcolm and Van Den Berg, David and Moysich, Kirsten and Ness, Roberta and Doherty, Jennifer and Rossing, Mary-Anne and Pearce, Celeste Leigh and Chenevix-Trench, Georgia (2009) Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortium. Twin research and human genetics : the official journal of the International Society for Twin Studies, 12 (3). pp. 269-275. ISSN 1832-4274

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Fibroblast growth factor (FGF)-2 (basic) is a potent angiogenic molecule involved in tumor progression, and is one of several growth factors with a central role in ovarian carcinogenesis. We hypothesized that common single nucleotide polymorphisms (SNPs) in the FGF2 gene may alter angiogenic potential and thereby susceptibility to ovarian cancer. We analyzed 25 FGF2 tgSNPs using five independent study populations from the United States and Australia. Analysis was restricted to non-Hispanic White women with serous ovarian carcinoma (1269 cases and 2829 controls). There were no statistically significant associations between any FGF2 SNPs and ovarian cancer risk. There were two nominally statistically significant associations between heterozygosity for two FGF2 SNPs (rs308379 and rs308447; p < .05) and serous ovarian cancer risk in the combined dataset, but rare homozygous estimates did not achieve statistical significance, nor were they consistent with the log additive model of inheritance. Overall genetic variation in FGF2 does not appear to play a role in susceptibility to ovarian cancer.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1375/twin.12.3.269
PubMed ID: 19456219
PMCID: PMC2844121
Grant Numbers: R01 CA122443, R01 CA087538, R01 CA112523, P30 CA014089, P01 CA017054, R01 CA063464
Keywords or MeSH Headings: Australia; Case-Control Studies; Female; Fibroblast Growth Factor 2/genetics; Humans; Ovarian Neoplasms/epidemiology/genetics; Polymorphism, Genetic; Population Groups/genetics; Risk Factors; Serous Membrane/pathology; United States;
Subjects: Cellular and Organismal Processes > Genetic processes > Mutation
Diseases > Solid tumors > Ovarian cancer
Research Methodologies > Epidemiology > Risk assessment
Depositing User: Library Staff
Date Deposited: 14 Sep 2009 20:47
Last Modified: 14 Feb 2012 14:42

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