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A role for a neo-sex chromosome in stickleback speciation.

Kitano, Jun and Ross, Joseph A. and Mori, Seiichi and Kume, Manabu and Jones, Felicity C. and Chan, Yingguang F. and Absher, Devin M. and Grimwood, Jane and Schmutz, Jeremy and Myers, Richard M. and Kingsley, David M. and Peichel, Catherine L. (2009) A role for a neo-sex chromosome in stickleback speciation. Nature, 461 (7267). pp. 1079-1083. ISSN 1476-4687

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Sexual antagonism, or conflict between the sexes, has been proposed as a driving force in both sex-chromosome turnover and speciation. Although closely related species often have different sex-chromosome systems, it is unknown whether sex-chromosome turnover contributes to the evolution of reproductive isolation between species. Here we show that a newly evolved sex chromosome contains genes that contribute to speciation in threespine stickleback fish (Gasterosteus aculeatus). We first identified a neo-sex chromosome system found only in one member of a sympatric species pair in Japan. We then performed genetic linkage mapping of male-specific traits important for reproductive isolation between the Japanese species pair. The neo-X chromosome contains loci for male courtship display traits that contribute to behavioural isolation, whereas the ancestral X chromosome contains loci for both behavioural isolation and hybrid male sterility. Our work not only provides strong evidence for a large X-effect on reproductive isolation in a vertebrate system, but also provides direct evidence that a young neo-X chromosome contributes to reproductive isolation between closely related species. Our data indicate that sex-chromosome turnover might have a greater role in speciation than was previously appreciated.

Item Type: Article or Abstract
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1038/nature08441
PubMed ID: 19783981
PMCID: PMC2776091
Grant Numbers: T32 GM07270, R01 GM071854, P50 HG02568
Keywords or MeSH Headings: * Animals * Body Size * Crosses, Genetic * Female * Genetic Speciation* * Hybridization, Genetic * Infertility, Male/genetics * Japan * Male * Mating Preference, Animal * Oceans and Seas * Pacific Ocean * Polymorphism, Single Nucleotide * Quantitative Trait Loci * Reproduction/genetics * Reproduction/physiology * Sex Characteristics * Sex Chromosomes/genetics* * Smegmamorpha/anatomy & histology * Smegmamorpha/classification * Smegmamorpha/genetics* * Smegmamorpha/physiology* * Social Isolation * Y Chromosome/genetics
Subjects: Cellular and Organismal Processes > Evolution
Organisms > Model organisms
Cellular and Organismal Processes > Reproduction
Depositing User: Library Staff
Date Deposited: 18 Feb 2010 19:54
Last Modified: 14 Feb 2012 14:42

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