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A prospective study of bowel motility and related factors on breast cancer risk.

Maruti, Sonia S and Lampe, Johanna W and Potter, John D and Ready, Ann and White, Emily (2008) A prospective study of bowel motility and related factors on breast cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (7). pp. 1746-1750. ISSN 1055-9965

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Abstract

BACKGROUND: Estrogen is an established risk factor for breast cancer. Greater bowel motility has been associated with increased estrogen excretion and lower serum estrogen levels, suggesting that it may influence breast cancer risk. However, only one other epidemiologic study thus far, to our knowledge, has examined the relation between bowel motility and breast cancer risk. METHODS: We prospectively examined whether bowel motility, measured by self-reported frequency of bowel movements, and related factors (constipation, laxative use, water consumption, and dietary fiber intake) were associated with incidence of breast cancer among 28,586 postmenopausal women, ages 50 to 76 years, in the Vitamins and Lifestyle study. Cox proportional hazards models were used to estimate multivariate-adjusted relative risks (RR) and 95% confidence intervals (95% CI). From 2000 to 2005, 507 incident invasive breast cancers among the cohort were identified. RESULTS: Women with very frequent (> or =3/d) bowel movements had a 46% decreased risk compared with 1/d women (RR, 0.54; 95% CI, 0.31-0.92), but the test for linear trend was not significant (P(trend) = 0.41). Constipation was nonsignificantly associated with increased risk (RR, 1.30 for > or =1/wk versus <1/y; 95% CI, 0.87-1.95). No statistically significant associations were observed for the other study exposures: 10-year chemical laxative use, 10-year use of fiber laxatives, water consumption, and dietary fiber intake. CONCLUSION: This study adds limited support to the hypothesis that increased bowel motility lowers breast cancer risk.

Item Type: Article
Additional Information: The final published version of this article is available at the URL above.
DOI: 10.1158/1055-9965.EPI-07-2850
PubMed ID: 18628427
NIHMSID: NIHMS169105
PMCID: PMC2848455
Grant Numbers: R01 CA74846, R25 CA94880
Keywords or MeSH Headings: Aged; Breast Neoplasms/epidemiology/etiology/physiopathology; Confidence Intervals; Female; Follow-Up Studies; Gastrointestinal Motility/physiology; Humans; Incidence; Middle Aged; Postmenopause; Prognosis; Proportional Hazards Models; Prospective Studies; Questionnaires; Risk Factors; Washington/epidemiology;
Subjects: Diseases > Solid tumors > Breast cancer
Research Methodologies > Epidemiology > Risk assessment
Depositing User: Library Staff
Date Deposited: 07 Jan 2010 18:11
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/351

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