Peichel, Catherine L and Abbott, C M and Vogt, T F (1996) Genetic and physical mapping of the mouse Ulnaless locus. Genetics, 144 (4). pp. 1757-1767. ISSN 0016-6731
Abstract
The mouse Ulnaless locus is a semidominant mutation which displays defects in patterning along the proximal-distal and anterior-posterior axes of all four limbs. The first Ulnaless homozygotes have been generated, and they display a similar, though slightly more severe, limb phenotype than the heterozygotes. To create a refined genetic map of the Ulnaless region using molecular markers, four backcrosses segregating Ulnaless were established. A 0.4-cM interval containing the Ulnaless locus has been defined on mouse chromosome 2, which has identified Ulnaless as a possible allele of a Hoxd cluster gene(s). With this genetic map as a framework, a physical map of the Ulnaless region has been completed. Yeast artificial chromosomes covering this region have been isolated and ordered into a 2 Mb contig. Therefore, the region that must contain the Ulnaless locus has been defined and cloned, which will be invaluable for the identification of the molecular nature of the Ulnaless mutation.
| Item Type: | Article or Abstract |
|---|---|
| Additional Information: | This article is available Open Access at PubMed Central via http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1207725&blobtype=pdf |
| PubMed ID: | 8978061 |
| PMCID: | PMC1207725 |
| Keywords or MeSH Headings: | Animals; Chromosome Mapping; Chromosomes, Artificial, Yeast; Genes, Dominant; Mice; Mutation; |
| Subjects: | Research Methodologies > Genomics Cellular and Organismal Processes > Genetic processes > Mutation Cellular and Organismal Processes > Development Research Methodologies > Genomics > Gene mapping |
| Depositing User: | Library Staff |
| Date Deposited: | 23 Sep 2008 16:50 |
| Last Modified: | 21 May 2010 16:43 |
| URI: | http://authors.fhcrc.org/id/eprint/37 |
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