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Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations.

Spitz, F and Gonzalez, F and Peichel, Catherine L and Vogt, T F and Duboule, D and Zákány, J (2001) Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations. Genes & development, 15 (17). pp. 2209-2214. ISSN 0890-9369

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Article URL: http://genesdev.cshlp.org/cgi/reprint/15/17/2209

Abstract

The ancestral role of the Hox gene family is specifying morphogenetic differences along the main body axis. In vertebrates, HoxD genes were also co-opted along with the emergence of novel structures such as limbs and genitalia. We propose that these functional recruitments relied on the appearance, or implementation, of regulatory sequences outside of the complex. Whereas transgenic human and murine HOXD clusters could function during axial patterning, in mice they were not expressed outside the trunk. Accordingly, deletion of the entire cluster abolished axial expression, whereas recently acquired regulatory controls were preserved.

Item Type: Article
Additional Information: Open Access to this article is available at PubMed Central. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11544178
DOI: 10.1101/gad.205701
PubMed ID: 11544178
PMCID: PMC312772
Keywords or MeSH Headings: Animals; Bone Development/genetics; DNA-Binding Proteins; Embryo, Mammalian/metabolism; Evolution, Molecular; Gene Deletion; Gene Expression Regulation, Developmental; Genes, Reporter; Homeodomain Proteins/genetics/physiology; Humans; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Models, Genetic; Multigene Family; Mutation; Neoplasm Proteins; Phenotype; Recombination, Genetic; Time Factors; Transcription Factors/genetics;
Subjects: Cellular and Organismal Processes > Development
Cellular and Organismal Processes > Genetic processes > Transcription
Depositing User: Library Staff
Date Deposited: 23 Sep 2008 16:51
Last Modified: 07 May 2010 21:38
URI: http://authors.fhcrc.org/id/eprint/40

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