Pierce, Brandon L and Biggs, Mary L and DeCambre, Marvalyn and Reiner, Alexander P and Li, Christopher and Fitzpatrick, Annette and Carlson, Christopher S and Stanford, Janet L and Austin, Melissa A (2009) C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older. Cancer causes & control : CCC, 20 (7). pp. 1193-1203. ISSN 1573-7225
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Abstract
Inflammation is believed to play a role in prostate cancer (PCa) etiology, but it is unclear whether inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6) associate with PCa risk in older men. Using Cox regression, we assessed the relationship between baseline concentrations of CRP and IL-6 and the subsequent PCa risk in the Cardiovascular Health Study, a population-based cohort study of mostly European American men of ages >64 years (n = 2,234; mean follow-up = 8.7 years; 215 incident PCa cases). We also tested associations between CRP and IL-6 tagSNPs and PCa risk, focusing on SNPs that are known to associate with circulating CRP and/or IL-6. Neither CRP nor IL-6 blood concentrations was associated with PCa risk. The C allele of IL-6 SNP rs1800795 (-174), a known functional variant, was associated with increased risk in a dominant model (HR = 1.44; 95% CI = 1.03-2.01; p = 0.03), but was not statistically significant after accounting for multiple tests (permutation p = 0.21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
| Item Type: | Article or Abstract |
|---|---|
| Additional Information: | The final publication is available at www.springerlink.com |
| DOI: | 10.1007/s10552-009-9320-4 |
| PubMed ID: | 19267250 |
| NIHMSID: | NIHMS186650 |
| PMCID: | PMC2846958 |
| Grant Numbers: | R25-CA94880, Contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC- 55222, N01-HC-75150, N01-HC-45133, U01 HL080295 |
| Keywords or MeSH Headings: | African Americans; Aged; Aged, 80 and over; Biological Markers/blood; C-Reactive Protein/genetics/metabolism; European Continental Ancestry Group; Humans; Inflammation/complications; Interleukin-6/blood/genetics; Male; Polymorphism, Single Nucleotide/genetics; Prospective Studies; Prostatic Neoplasms/epidemiology/metabolism; Risk Factors; |
| Subjects: | Research Methodologies > Genomics > Molecular Markers Research Methodologies > Epidemiology > Risk assessment Diseases > Solid tumors > Prostate cancer |
| Depositing User: | Library Staff |
| Date Deposited: | 10 Mar 2010 19:07 |
| Last Modified: | 14 Feb 2012 14:43 |
| URI: | http://authors.fhcrc.org/id/eprint/404 |
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