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C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

Pierce, Brandon L and Biggs, Mary L and DeCambre, Marvalyn and Reiner, Alexander P and Li, Christopher and Fitzpatrick, Annette and Carlson, Christopher S and Stanford, Janet L and Austin, Melissa A (2009) C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older. Cancer causes & control : CCC, 20 (7). pp. 1193-1203. ISSN 1573-7225

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Article URL: http://www.springerlink.com/content/c570717620803n...

Abstract

Inflammation is believed to play a role in prostate cancer (PCa) etiology, but it is unclear whether inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6) associate with PCa risk in older men. Using Cox regression, we assessed the relationship between baseline concentrations of CRP and IL-6 and the subsequent PCa risk in the Cardiovascular Health Study, a population-based cohort study of mostly European American men of ages >64 years (n = 2,234; mean follow-up = 8.7 years; 215 incident PCa cases). We also tested associations between CRP and IL-6 tagSNPs and PCa risk, focusing on SNPs that are known to associate with circulating CRP and/or IL-6. Neither CRP nor IL-6 blood concentrations was associated with PCa risk. The C allele of IL-6 SNP rs1800795 (-174), a known functional variant, was associated with increased risk in a dominant model (HR = 1.44; 95% CI = 1.03-2.01; p = 0.03), but was not statistically significant after accounting for multiple tests (permutation p = 0.21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.

Item Type: Article
Additional Information: The final publication is available at www.springerlink.com
DOI: 10.1007/s10552-009-9320-4
PubMed ID: 19267250
NIHMSID: NIHMS186650
PMCID: PMC2846958
Grant Numbers: R25-CA94880, Contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC- 55222, N01-HC-75150, N01-HC-45133, U01 HL080295
Keywords or MeSH Headings: African Americans; Aged; Aged, 80 and over; Biological Markers/blood; C-Reactive Protein/genetics/metabolism; European Continental Ancestry Group; Humans; Inflammation/complications; Interleukin-6/blood/genetics; Male; Polymorphism, Single Nucleotide/genetics; Prospective Studies; Prostatic Neoplasms/epidemiology/metabolism; Risk Factors;
Subjects: Research Methodologies > Genomics > Molecular Markers
Research Methodologies > Epidemiology > Risk assessment
Diseases > Solid tumors > Prostate cancer
Depositing User: Library Staff
Date Deposited: 10 Mar 2010 19:07
Last Modified: 14 Feb 2012 14:43
URI: http://authors.fhcrc.org/id/eprint/404

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