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Clinical and virologic efficacy of herpes simplex virus type 2 suppression by acyclovir in a multicontinent clinical trial.

Fuchs, Jonathan and Celum, Connie and Wang, Jing and Hughes, James and Sanchez, Jorge and Cowan, Frances and Reid, Stewart and Delany-Moretlwe, Sinead and Corey, Lawrence and Wald, Anna (2010) Clinical and virologic efficacy of herpes simplex virus type 2 suppression by acyclovir in a multicontinent clinical trial. The Journal of infectious diseases, 201 (8). pp. 1164-1168. ISSN 1537-6613

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Article URL: http://www.journals.uchicago.edu/doi/abs/10.1086/6...

Abstract

Acyclovir suppressive therapy (400 mg twice daily) reduces herpes simplex virus (HSV) type 2-associated genital ulcer disease and lesional HSV shedding. In an international trial of acyclovir for suppression of HSV type 2 to prevent human immunodeficiency virus (HIV) acquisition (HIV Prevention Trials Network 039), acyclovir had a smaller effect on the frequency of genital ulcer disease as well as a smaller effect on the frequency and quantity of lesional HSV DNA in African women and Peruvian men, compared with its effects in men in the United States. The observed regional variation in the clinical and virologic efficacy of acyclovir for HSV suppression warrants further evaluation of determinants of responses to acyclovir. (ClinicalTrials.gov identifier: NCT00076232.).

Item Type: Article
Additional Information: This article is article is available to subscribers only via the URL above.
DOI: 10.1086/651381
PubMed ID: 20214474
NIHMSID: NIHMS192068
PMCID: PMC2856478
Grant Numbers: U01 AI052054-06, P01 AI030731-19, U01 AI046749-05
Keywords or MeSH Headings: * Acyclovir/therapeutic use* * Antiviral Agents/therapeutic use* * Female * HIV Infections/prevention & control * Herpes Genitalis/drug therapy* * Herpesvirus 2, Human/drug effects* * Humans * Male * Peru * South Africa * United States * Virus Shedding/drug effects * Zambia * Zimbabwe
Subjects: Diseases > Viral diseases
Therapeutics > Drug Therapy
Depositing User: Library Staff
Date Deposited: 16 Apr 2010 22:54
Last Modified: 14 Feb 2012 14:43
URI: http://authors.fhcrc.org/id/eprint/417

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