Arnold Library

Spatial clustering of myelodysplastic syndromes (MDS) in the Seattle-Puget Sound region of Washington State.

Ross, Michelle E and Wakefield, Jon and Davis, Scott and De Roos, Anneclaire J (2010) Spatial clustering of myelodysplastic syndromes (MDS) in the Seattle-Puget Sound region of Washington State. Cancer causes & control : CCC, 21 (6). pp. 829-838. ISSN 1573-7225

[thumbnail of Complete manuscript]
Text (Complete manuscript)
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Preview
Article URL:


OBJECTIVES: Incidence of myelodysplastic syndromes (MDS) has been described in the United States since its inclusion in the Surveillance, Epidemiology, and End Results program in 2001, and the Seattle-Puget Sound region of Washington State has among the highest rates of the registries. In this investigation, we described small-scale incidence patterns of MDS within the Seattle-Puget Sound region from 2002 to 2006 and identified potential spatial clusters to inform planning of future studies of MDS etiology. METHODS: We used a spatial disease mapping model to estimate smoothed relative risks for each census tract and to describe the spatial component of variability in the incidence rates. We also used two methods to describe the location of potential MDS clusters: the approach of Besag and Newell and the Kulldorff spatial scan statistic. RESULTS: Our findings from all three approaches indicated the most likely areas of increased MDS incidence were located on Whidbey Island in Island County. CONCLUSION: Interpretation is limited because our data are based on the residential location of the MDS case only at the time of diagnosis. Nevertheless, inclusion of identified cluster regions in future population-based research and investigation of individual-level exposures could shed light on environmental risk factors for MDS.

Item Type: Article or Abstract
Additional Information: The original publication is available at
DOI: 10.1007/s10552-010-9509-6
PubMed ID: 20101455
Grant Numbers: R01 CA095994-04, NO1-PC-55020-20
Keywords or MeSH Headings: Cluster Analysis Female Humans Incidence Male Myelodysplastic Syndromes/epidemiology* Registries Risk Factors United States/epidemiology Washington
Depositing User: Library Staff
Date Deposited: 06 Aug 2010 20:37
Last Modified: 14 Feb 2012 14:43

Repository Administrators Only

View Item View Item