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Rho GTPase function in flies: insights from a developmental and organismal perspective.

Johndrow, James E and Magie, Craig R and Parkhurst, Susan M (2004) Rho GTPase function in flies: insights from a developmental and organismal perspective. Biochemistry and cell biology = Biochimie et biologie cellulaire, 82 (6). pp. 643-57. ISSN 0829-8211

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Morphogenesis is a key event in the development of a multicellular organism and is reliant on coordinated transcriptional and signal transduction events. To establish the segmented body plan that underlies much of metazoan development, individual cells and groups of cells must respond to exogenous signals with complex movements and shape changes. One class of proteins that plays a pivotal role in the interpretation of extracellular cues into cellular behavior is the Rho family of small GTPases. These molecular switches are essential components of a growing number of signaling pathways, many of which regulate actin cytoskeletal remodeling. Much of our understanding of Rho biology has come from work done in cell culture. More recently, the fruit fly Drosophila melanogaster has emerged as an excellent genetic system for the study of these proteins in a developmental and organismal context. Studies in flies have greatly enhanced our understanding of pathways involving Rho GTPases and their roles in development.

Item Type: Article or Abstract
DOI: 10.1139/o04-118
PubMed ID: 15674432
Grant Numbers: GM066847
Keywords or MeSH Headings: Animals; Drosophila Proteins/physiology; Drosophila melanogaster/embryology/enzymology/metabolism; Mutation; Signal Transduction; rho GTP-Binding Proteins/genetics/physiology;
Subjects: Cellular and Organismal Processes > Cell Physiology > Cell communication
Organisms > Model organisms
Cellular and Organismal Processes > Development
Molecules > Proteins
Depositing User: Library Staff
Date Deposited: 17 Sep 2008 21:24
Last Modified: 14 Feb 2012 14:42

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