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Lack of utility of chimerism studies obtained 2-3 months after myeloablative hematopoietic cell transplantation for ALL.

Doney, Kc and Loken, Mr and Bryant, Em and Smith, Ag and Appelbaum, Fr (2008) Lack of utility of chimerism studies obtained 2-3 months after myeloablative hematopoietic cell transplantation for ALL. Bone marrow transplantation, 42 (4). pp. 271-274. ISSN 0268-3369

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Article URL: http://www.nature.com/bmt/journal/v42/n4/full/bmt2...

Abstract

Lineage-specific chimerism studies are commonly obtained at several time points after nonmyeloablative hematopoietic cell transplantation to assess the tempo and degree of engraftment, and to monitor graft rejection. For patients who receive myeloablative transplants, the value of frequent chimerism analyses using sensitive molecular techniques is less certain. In this study, a retrospective analysis was performed to assess the transplant outcome of 89 adult patients with ALL who had chimerism studies of unfractionated BM cells or peripheral blood subsets performed approximately 80 days after transplantation. These patients received unmanipulated, myeloablative transplants using either HLA-identical or HLA-mismatched, related or unrelated donor stem cells. Incomplete donor engraftment was present only in the CD3+ peripheral blood T cells in a small percentage of patients. There was no correlation of mixed chimerism with transplant outcome. Routine 'day 80' chimerism studies in this group of patients who receive intensive, myeloablative conditioning regimens are not recommended.

Item Type: Article
DOI: 10.1038/bmt.2008.155
PubMed ID: 18500370
NIHMSID: NIHMS262856
PMCID: PMC3044127
Keywords or MeSH Headings: Adolescent; Adult; Female; Hematopoietic Stem Cell Transplantation/methods; Humans; Male; Middle Aged; Myeloablative Agonists/therapeutic use; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology/therapy; Transplantation Chimera/immunology; Transplantation Conditioning/methods;
Subjects: Diseases > Hematologic and lymphatic diseases > Leukemia
Therapeutics > Transplantation > Stem Cell transplantation
Depositing User: Library Staff
Date Deposited: 19 Jan 2011 23:59
Last Modified: 14 Feb 2012 14:43
URI: http://authors.fhcrc.org/id/eprint/470

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