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Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials.

Koreth, John and Schlenk, Richard and Kopecky, Kenneth J and Honda, Sumihisa and Sierra, Jorge and Djulbegovic, Benjamin J and Wadleigh, Martha and DeAngelo, Daniel J and Stone, Richard M and Sakamaki, Hisashi and Appelbaum, Frederick R and Döhner, Hartmut and Antin, Joseph H and Soiffer, Robert J and Cutler, Corey (2009) Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA : the journal of the American Medical Association, 301 (22). pp. 2349-2361. ISSN 1538-3598

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Article URL: http://jama.ama-assn.org/content/301/22/2349.long

Abstract

The optimal treatment of acute myeloid leukemia (AML) in first complete remission (CR1) is uncertain. Current consensus, based on cytogenetic risk, recommends myeloablative allogeneic stem cell transplantation (SCT) for poor-risk but not for good-risk AML. Allogeneic SCT, autologous transplantation, and consolidation chemotherapy are considered of equivalent benefit for intermediate-risk AML.

Item Type: Article
Additional Information: The final published article is freely available at the URL above.
DOI: 10.1001/jama.2009.813
PubMed ID: 19509382
NIHMSID: NIHMS263072
PMCID: PMC3163846
Grant Numbers: CA 18029
Keywords or MeSH Headings: Antineoplastic Agents/therapeutic use; Clinical Trials as Topic; Humans; Leukemia, Myeloid, Acute/mortality/therapy; Remission Induction; Risk Assessment; Stem Cell Transplantation; Survival Analysis; Transplantation, Homologous;
Subjects: Diseases > Hematologic and lymphatic diseases > Leukemia
Therapeutics > Transplantation > Stem Cell transplantation
Depositing User: Library Staff
Date Deposited: 07 Jan 2011 20:11
Last Modified: 14 Feb 2012 14:43
URI: http://authors.fhcrc.org/id/eprint/473

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