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High prevalence of metabolic syndrome after allogeneic hematopoietic cell transplantation.

Majhail, Navneet S and Flowers, Mary E and Ness, Kirsten K and Jagasia, Madan and Carpenter, Paul A and Arora, Mukta and Arai, Sally and Johnston, Laura and Martin, Paul J and Baker, K Scott and Lee, Stephanie J and Burns, Linda J (2008) High prevalence of metabolic syndrome after allogeneic hematopoietic cell transplantation. Bone marrow transplantation. ISSN 0268-3369 (In Press)

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We conducted a cross-sectional study to estimate the prevalence of metabolic syndrome, a clustering of risk factors associated with cardiovascular disease, among 86 adults who had allogeneic hematopoietic-cell transplant (HCT) as compared with 258 age- and gender-matched US population controls selected from the 2005-2006 National Health and Nutrition Examination Survey database. The median age at study enrollment was 50 years (range, 21-71), and patients were at a median of 3 years (range, 1-21) from HCT. The prevalence of metabolic syndrome was 49% (95% confidence intervals (CI), 38-60%) among HCT recipients, a 2.2-fold (95% CI, 1.3-3.6, P=0.002) increase compared with controls. The prevalence rates of elevated blood pressure and hypertriglyceridemia were significantly higher among HCT recipients than among controls, but the prevalence rates of abdominal obesity, elevated blood glucose and low high-density lipoprotein cholesterol were not. HCT survivors with metabolic syndrome were more likely to have microalbuminuria (43 vs 10%) and elevated creatinine (31 vs 11%). No patient, donor or transplant characteristics were associated with the diagnosis of metabolic syndrome. We conclude that metabolic syndrome occurs frequently among allogeneic HCT survivors who are seen by transplant physicians. Approaches to screening, prevention and management of metabolic syndrome should be developed for HCT recipients.

Item Type: Article or Abstract
DOI: 10.1038/bmt.2008.263
PubMed ID: 18724397
PMCID: PMC2628412
Grant Numbers: P30 CA015704-34
Keywords or MeSH Headings: Adult Aged Case-Control Studies Cross-Sectional Studies Female Hematopoietic Stem Cell Transplantation* Humans Male Metabolic Syndrome X/epidemiology* Metabolic Syndrome X/etiology Middle Aged Prevalence Risk Factors Transplantation Conditioning Transplantation, Homologous Young Adult
Subjects: Diseases
Therapeutics > Transplantation > Stem Cell transplantation
Research Methodologies > Epidemiology
Depositing User: Library Staff
Date Deposited: 25 Sep 2008 17:55
Last Modified: 14 Feb 2012 14:42

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