Loo, Lenora W M and Wang, Yinghui and Flynn, Erin M and Lund, Mary Jo and Bowles, Erin J Aiello and Buist, Diana S M and Liff, Jonathan M and Flagg, Elaine W and Coates, Ralph J and Eley, J William and Hsu, Li and Porter, Peggy L (2011) Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women. Breast cancer research and treatment, 127 (1). pp. 297-308. ISSN 1573-7217
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Abstract
Genomic copy number alterations (CNA) are common in breast cancer. Identifying characteristic CNAs associated with specific breast cancer subtypes is a critical step in defining potential mechanisms of disease initiation and progression. We used genome-wide array comparative genomic hybridization to identify distinctive CNAs in breast cancer subtypes from 259 young (diagnosed with breast cancer at <55 years) African American (AA) and Caucasian American (CA) women originally enrolled in a larger population-based study. We compared the average frequency of CNAs across the whole genome for each breast tumor subtype and found that estrogen receptor (ER)-negative tumors had a higher average frequency of genome-wide gain (P < 0.0001) and loss (P = 0.02) compared to ER-positive tumors. Triple-negative (TN) tumors had a higher average frequency of genome-wide gain (P < 0.0001) and loss (P = 0.003) than non-TN tumors. No significant difference in CNA frequency was observed between HER2-positive and -negative tumors. We also identified previously unreported recurrent CNAs (frequency >40%) for TN breast tumors at 10q, 11p, 11q, 16q, 20p, and 20q. In addition, we report CNAs that differ in frequency between TN breast tumors of AA and CA women. This is of particular relevance because TN breast cancer is associated with higher mortality and young AA women have higher rates of TN breast tumors compared to CA women. These data support the possibility that higher overall frequency of genomic alteration events as well as specific focal CNAs in TN breast tumors might contribute in part to the poor breast cancer prognosis for young AA women.
| Item Type: | Article or Abstract |
|---|---|
| Additional Information: | The final publication is available at www.springerlink.com |
| DOI: | 10.1007/s10549-010-1297-x |
| PubMed ID: | 21264507 |
| NIHMSID: | 318789 |
| Grant Numbers: | R01 CA064292, R01 CA098415 |
| Keywords or MeSH Headings: | Adult; African Americans/genetics; Age Factors; Breast Neoplasms/genetics/pathology; Cluster Analysis; Comparative Genomic Hybridization; DNA Copy Number Variations/genetics; European Continental Ancestry Group/genetics; Female; Gene Frequency; Genome-Wide Association Study; Humans; Middle Aged; Young Adult; |
| Depositing User: | Library Staff |
| Date Deposited: | 16 Aug 2011 21:52 |
| Last Modified: | 16 Sep 2015 07:17 |
| URI: | http://authors.fhcrc.org/id/eprint/495 |
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