Allogeneic Stem Cell Transplantation for Multiple Myeloma: A Review of Outcomes at a single Transplant Center

Bensinger, William I and Rotta, Marcello and Storer, Barry and Chauncey, Tom and Holmberg, Leona and Becker, Pam and Sandmaier, Brenda M. and Storb, Rainer and Maloney, David Allogeneic Stem Cell Transplantation for Multiple Myeloma: A Review of Outcomes at a single Transplant Center. Bone Marrow Transplantation. ISSN 0268-3369 (In Press)

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Abstract

Allogeneic stem cell transplant for multiple myeloma (MM) is one treatment associated with long term disease free survival. The high incidence of treatment related mortality and relapses, however, are important reasons for controversy about the role of allografting in the management of MM. We reviewed our results of allografting for MM spanning a period of 34 years in order to better define long term outcomes and identify areas of progress as well as areas needing improvement. A total of 278 patients received allogeneic marrow or peripheral blood stem cells after high dose myeloablative (N=144) or reduced intensity, non-myeloablative (N=134) regimens. In multivariable analysis, adjusting for differences in patient groups, reduced intensity/nonmyeloablative transplants were associated with significantly less acute GVHD, lower transplant mortality, better progression free survival and overall survival. There were no significant differences in relapse, progression or chronic GVHD, when adjusted. In multivariable analysis of patients receiving only non-myeloablative transplants, decreased overall survival and progression free survival were associated with relapse after a prior autograft and a ß2 microglobulin >4.0. Transplant mortality was reduced and only influenced by a prior tandem autograft.

Item Type:	Article or Abstract
DOI:	10.1038/bmt.2012.1
PubMed ID:	22327126
NIHMSID:	NIHMS347446
Grant Numbers:	CA78902, CA 155911, CA 18029, CA 15704
Depositing User:	Library Staff
Date Deposited:	09 May 2012 22:41
Last Modified:	09 May 2012 22:41
URI:	http://authors.fhcrc.org/id/eprint/520

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