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In Vivo Bio-imaging Using Chlorotoxin-based Conjugates.

Stroud, Mark R and Hansen, Stacey J and Olson, James M (2011) In Vivo Bio-imaging Using Chlorotoxin-based Conjugates. Current pharmaceutical design, 17 (38). pp. 4362-71. ISSN 1873-4286

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Surgical resection remains the primary component of cancer therapy. The precision required to successfully separate cancer tissue from normal tissue relies heavily on the surgeon's ability to delineate the tumor margins. Despite recent advances in surgical guidance and monitoring systems, intra-operative identification of these margins remains imprecise and directly influences patient prognosis. If the surgeon had improved tools to distinguish these margins, tumor progression and unacceptable morbidity could be avoided. In this article, we review the history of chlorotoxin and its tumor specificity and discuss the research currently being generated to target optical imaging agents to cancer tissue.

Item Type: Article or Abstract
PubMed ID: 22204434
Grant Numbers: R01CA135491, R01CA112350, R01CA119408, R01CA134213-01, R01CA134213-02, R01EB006043-01, R01EB006043-02
Depositing User: Library Staff
Date Deposited: 12 Jan 2012 20:29
Last Modified: 16 Sep 2015 07:17

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