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Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV.

Wootton, Sarah K and Metzger, Michael J and Hudkins, Kelly L and Alpers, Charles E and York, Denis and DeMartini, James C and Miller, A Dusty (2006) Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV. Retrovirology, 3. p. 94. ISSN 1742-4690

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Article URL: http://www.retrovirology.com/content/3/1/94

Abstract

Lung cancers induced by JSRV infection in sheep and by JSRV Env expression in mice have similar histologic features and are primarily characterized by adenomatous proliferation of peripheral lung epithelial cells. Thus it is unnecessary to invoke a role for insertional mutagenesis, gene activation, viral replication, or expression of other viral gene products in sheep lung tumorigenesis, although these processes may play a role in other clinically less important sequelae of JSRV infection such as metastasis observed with variable frequency in sheep.

Item Type: Article
DOI: 10.1186/1742-4690-3-94
PubMed ID: 17177996
PMCID: PMC1764900
Depositing User: Library Staff
Date Deposited: 16 Mar 2012 18:57
Last Modified: 16 Mar 2012 18:57
URI: http://authors.fhcrc.org/id/eprint/554

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