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Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.

Greer, Elisabeth R and Pérez, Carissa L and Van Gilst, Marc R and Lee, Brian H and Ashrafi, Kaveh (2008) Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell metabolism, 8 (2). pp. 118-131. ISSN 1932-7420

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Article URL: http://www.sciencedirect.com/science?_ob=ArticleUR...

Abstract

A major challenge in understanding energy balance is deciphering the neural and molecular circuits that govern behavioral, physiological, and metabolic responses of animals to fluctuating environmental conditions. The neurally expressed TGF-beta ligand DAF-7 functions as a gauge of environmental conditions to modulate energy balance in C. elegans. We show that daf-7 signaling regulates fat metabolism and feeding behavior through a compact neural circuit that allows for integration of multiple inputs and the flexibility for differential regulation of outputs. In daf-7 mutants, perception of depleting food resources causes fat accumulation despite reduced feeding rate. This fat accumulation is mediated, in part, through neural metabotropic glutamate signaling and upregulation of peripheral endogenous biosynthetic pathways that direct energetic resources into fat reservoirs. Thus, neural perception of adverse environmental conditions can promote fat accumulation without a concomitant increase in feeding rate.

Item Type: Article
DOI: 10.1016/j.cmet.2008.06.005
PubMed ID: 18680713
NIHMSID: NIHMS65743
PMCID: PMC2556218
Keywords or MeSH Headings: Adaptation, Physiological/physiology Adipose Tissue/metabolism Animals Appetite Regulation/physiology* Caenorhabditis elegans/cytology Caenorhabditis elegans/metabolism* Caenorhabditis elegans Proteins/genetics Caenorhabditis elegans Proteins/metabolism Energy Metabolism/physiology Environment Feeding Behavior/physiology* Lipid Metabolism/physiology* Models, Animal Mutation/genetics Nervous System/cytology Nervous System/metabolism* Neural Pathways/cytology Neural Pathways/metabolism Neurons, Afferent/cytology Neurons, Afferent/metabolism* Receptors, Metabotropic Glutamate/metabolism Starvation/metabolism Transforming Growth Factor beta/genetics Transforming Growth Factor beta/metabolism
Subjects: Cellular and Organismal Processes > Cell Physiology > Cell communication
Cell Types > Neurons
Cellular and Organismal Processes > Metabolism
Depositing User: Library Staff
Date Deposited: 24 Sep 2008 20:06
Last Modified: 13 Oct 2011 23:13
URI: http://authors.fhcrc.org/id/eprint/56

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