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Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis

FitzGerald, Liesel M. and Karlins, Eric and Karyadi, Danielle M. and Kwon, Erika M. and Koopmeiners, Joseph S. and Stanford, Janet L. and Ostrander, Elaine A. (2009) Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis. Prostate Cancer and Prostatic Diseases, 12 (2). pp. 192-197. ISSN 1476-5608

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Article URL: http://www.nature.com/pcan/journal/vaop/ncurrent/a...

Abstract

The fibroblast growth factor receptor 4 (FGFR4) is thought to be involved in many critical cellular processes and has been associated with prostate cancer risk. Four single nucleotide polymorphisms within or near FGFR4 were analysed in a population-based study of 1458 prostate cancer patients and 1352 age-matched controls. We found no evidence to suggest that any of the FGFR4 SNP genotypes were associated with prostate cancer risk or with disease aggressiveness, Gleason score or stage. A weak association was seen between rs351855 and prostate cancer-specific mortality. Subset analysis of cases that had undergone radical prostatectomy revealed an association between rs351855 and prostate cancer risk. While our results confirm an association between FGFR4 and prostate cancer risk in radical prostatectomy cases, they suggest that the role of FGFR4 in disease risk and outcomes at a population-based level appears to be minor.

Item Type: Article
Additional Information: This article is available to subscribers only via the URL above.
DOI: 10.1038/pcan.2008.46
PubMed ID: 18762813
NIHMSID: NIHMS71384
PMCID: PMC2790323
Grant Numbers: R01 CA056678-05, R01 CA082664-03, R01 CA092579-05, P50 CA097186-07
Keywords or MeSH Headings: * Adenocarcinoma/genetics* * Adenocarcinoma/surgery * Adult * Aged * Case-Control Studies * Genetic Predisposition to Disease * Humans * Male * Middle Aged * Polymorphism, Single Nucleotide* * Prognosis * Prostatectomy * Prostatic Neoplasms/genetics* * Prostatic Neoplasms/surgery * Receptor, Fibroblast Growth Factor, Type 4/genetics* * Risk Factors * Tumor Markers, Biological/genetics*
Subjects: Molecules > Proteins > Receptors
Research Methodologies > Epidemiology > Risk assessment
Diseases > Solid tumors > Prostate cancer
Depositing User: authors@FHCRC Administrator-Import
Date Deposited: 26 Sep 2008 20:21
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/64

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