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Diversity and function of orphan nuclear receptors in nematodes.

Van Gilst, Marc and Gissendanner, Christopher R and Sluder, Ann E (2002) Diversity and function of orphan nuclear receptors in nematodes. Critical reviews in eukaryotic gene expression, 12 (1). pp. 65-88. ISSN 1045-4403

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Nuclear receptors (NRs) have key regulatory functions in a wide range of biological processes and are one of the most abundant classes of transcriptional regulators in metazoans. NRs are particularly numerous in nematodes, in which the NR gene family has undergone extensive expansion and diversification, providing an evolutionary structure function experiment that is yielding new perspectives on the mechanisms of NR function and on nematode biology. The genome sequence of the free-living nematode Caenorhabditis elegans reveals 270 predicted NR genes, more than fivefold more than observed for any other species to date, though existing data suggest that NR genes are similarly abundant in other nematodes. Most of the currently available information regarding the functions of nematode NRs comes from ongoing studies with C. elegans, and we review here what has been learned thus far in three key areas: the relationships of C. elegans NRs to those in other species; the biochemical consequences of nematode NR sequence diversity.

Item Type: Article or Abstract
DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i1.40
PubMed ID: 12433066
Keywords or MeSH Headings: Amino Acid Sequence; Animals; Caenorhabditis elegans/metabolism; DNA/metabolism; DNA-Binding Proteins/chemistry/classification/metabolism/physiology; Ligands; Molecular Sequence Data; Receptors, Cytoplasmic and Nuclear/chemistry/classification/metabolism/physiology;
Subjects: Cellular and Organismal Processes > Evolution
Organisms > Model organisms
Molecules > Proteins > Receptors
Depositing User: Library Staff
Date Deposited: 30 Sep 2008 18:41
Last Modified: 07 May 2010 21:40

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